机构：[1]Central Laboratory, Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Key Laboratory for Neurodegenerative Disease of Ministry of Education, Xuan Wu Hospital, Capital Medical University, Department of Liver Cancer Center, Beijing 302 Hospital, Beijing, China首都医科大学宣武医院[2]Central Laboratory, Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Key Laboratory for Neurodegenerative Disease of Ministry of Education, Xuan Wu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院
Alzheimer's disease (AD) is one of the most common and devastating aging-related neurodegenerative diseases. Besides the well-known role of chemokines and their receptors in the immune system, they are widely expressed in the nervous system, where they play roles in the regulation of cell migration and neurotransmission. The chemokine CXC motif receptor 4 (CXCR4) is evolutionarily highly conserved seven-transmembrane G-protein-coupled receptors (GPCRs). It has been demonstrated that CXCL12/CXCR4 signaling pathway involved in the pathologic process of AD. In this review, we demonstrated the GPCR family proteins and summarized the relationship between CXCR4 and GPCR, CXCR4 and AD. The review aimed to provide the novel insight of CXCR4 into the early prevention of mild cognitive impairment and in the diagnosis and treatment of AD.
基金：
Supported by National Natural
Science Foundation of China (NO.81502553)Hongyan Li;
China Postdoctoral Science Foundation (2017M610947)
Hongyan Li; China Postdoctoral Science Foundation
(2017T100091)Hongyan Li; Beijing Postdoctoral Research
Foundation (2017zz‑115)Hongyan Li.
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[1989]版：
无
最新[2023]版：
大类|4 区医学
小类|4 区临床神经病学4 区神经科学
第一作者：
第一作者机构：[1]Central Laboratory, Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Key Laboratory for Neurodegenerative Disease of Ministry of Education, Xuan Wu Hospital, Capital Medical University, Department of Liver Cancer Center, Beijing 302 Hospital, Beijing, China
通讯作者：
通讯机构：[2]Central Laboratory, Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Key Laboratory for Neurodegenerative Disease of Ministry of Education, Xuan Wu Hospital, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Hongyan Li,Rong Wang.A focus on CXCR4 in Alzheimer's disease.[J].Brain circulation.1990,3(4):199-203.doi:10.4103/bc.bc_13_17.
APA：
Hongyan Li&Rong Wang.(1990).A focus on CXCR4 in Alzheimer's disease..Brain circulation,3,(4)
MLA：
Hongyan Li,et al."A focus on CXCR4 in Alzheimer's disease.".Brain circulation 3..4(1990):199-203
