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Targeting G protein-coupled receptor for pain management.

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机构: [1]Department of Pain Management, Xuanwu Hospital of Capital Medical University, Beijing100053, China. [2]Department of Central Laboratory, Xuanwu Hospital of Capital Medical University, Beijing 100053, [3]Department of Liver Cancer Center, The 302 Hospital, Beijing 100039, China, [4]Department of Immunogenetics Laboratory, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
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关键词: CXC receptor 4 Chemokine receptors chemokines opioid receptor pain

摘要:
Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage. Great progress has been made in understanding the important roles of various G protein-coupled receptors in the regulation of pain transmission. However, many important questions remain uncertain about the precise signal transduction mechanisms. This review focuses opioid receptor and CXC receptor 4 on the effects and mechanisms of pain. Taken together, chemokines and their receptors are potential targets for the development of novel pain management and therapy.

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最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 临床神经病学 4 区 神经科学
第一作者:
第一作者机构: [1]Department of Pain Management, Xuanwu Hospital of Capital Medical University, Beijing100053, China. [2]Department of Central Laboratory, Xuanwu Hospital of Capital Medical University, Beijing 100053, [3]Department of Liver Cancer Center, The 302 Hospital, Beijing 100039, China,
通讯作者:
通讯机构: [1]Department of Pain Management, Xuanwu Hospital of Capital Medical University, Beijing100053, China. [2]Department of Central Laboratory, Xuanwu Hospital of Capital Medical University, Beijing 100053, [3]Department of Liver Cancer Center, The 302 Hospital, Beijing 100039, China,
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