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Effects of Intraperitoneal and Intrathecal Morphine Analgesia on the Expression of mu-Opioid Receptors in Bone Cancer Pain Rats

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机构: [1]Capital Med Univ, Beijing Chest Hosp, Dept Anesthesiol, 97 Ma Chang, Beijing, Peoples R China; [2]Capital Med Univ, Beijing Childrens Hosp, Dept Anesthesiol, Beijing, Peoples R China; [3]Capital Med Univ, Beijing Chest Hosp, Lab Mol Biol, Beijing, Peoples R China; [4]Univ Louisville, Dept Anesthesiol & Perioperat Med, Louisville, KY 40292 USA; [5]Jewish Hosp, Dept Anesthesia, Louisville, KY USA
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关键词: intrathecal injection morphine mu-opioid receptor cancer pain

摘要:
Backgrounds: This study compared analgesic effects and mu-opioid receptor expression levels during long-term intraperitoneal and intrathecal treatment in a bone cancer pain rat. Methods: Twenty-four female Sprague-Dawley rats were injected Walker 256 tumor cells into the femur to create a bone cancer pain model. The control group was injected with saline intraperitoneally and intrathecally. The intraperitoneal group was injected with morphine intraperitoneally and saline intrathecally. The intrathecal group was injected saline intraperitoneally and morphine intrathecally. Changes in pain threshold, mu-opioid receptor expression levels in spinal cord, and tumor tissue were compared between 3 groups. Results: The intrathecal morphine group and the intraperitoneal group showed no difference in analgesia effects (P > .05). Western blot and immunohistochemical staining of mu-opioid receptors demonstrated that its level in the intrathecal group was significantly lower than the intraperitoneal group (P < .05) and without significant difference with the control group (P > .05). The expression levels of mu-opioid receptor in the spinal cord tissue did not reveal a difference among these 3 groups (P > .05). Conclusion: Intrathecal group and intraperitoneal group showed significant difference in mu-opioid receptor expressions although with no difference in analgesia effects. Long-term intrathecal morphine administration provided similar analgesia compared to systemic morphine.

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出版当年[2018]版:
大类 | 4 区 医学
小类 | 3 区 核医学 4 区 药学
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 药学 4 区 核医学
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出版当年[2017]版:
Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Q3 PHARMACOLOGY & PHARMACY
最新[2023]版:
Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Q3 PHARMACOLOGY & PHARMACY

影响因子: 最新[2023版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

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第一作者机构: [1]Capital Med Univ, Beijing Chest Hosp, Dept Anesthesiol, 97 Ma Chang, Beijing, Peoples R China;
通讯作者:
通讯机构: [1]Capital Med Univ, Beijing Chest Hosp, Dept Anesthesiol, 97 Ma Chang, Beijing, Peoples R China;
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