机构：[1]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China,神经内科[2]Department of Functional Neurosurgery, Xuanwu Hospital of Capital Medical University, Beijing, China,神经外科[3]Department of Radiology, Mayo Clinic, Jacksonville, FL, United States,[4]Department of Neurologic Surgery, Mayo Clinic, Jacksonville, FL, United States,[5]Department of Neurology, Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United States
Freezing of gait (FoG) is commonly observed in advanced Parkinson's disease (PD) and it is associated with reduced mobility, recurrent falls, injuries, and loss of independence. This phenomenon typically occurs as the effect of dopaminergic medications wears off ("off" FoG) but on rare occasions, it can also be observed during peak medication effect ("on" FoG). In this report, we present the case of a 65-year-old female with a 13-year history of akinetic-rigid idiopathic PD who developed recurrent episodes of "on" FoG after bilateral subthalamic nucleus deep brain stimulation (STN-DBS). She underwent STN-DBS for management of motor fluctuations, which resulted in a marked improvement in her motor symptoms. Within the next 6 months and after several programming sessions, the patient reported "on" FoG occurring regularly 1 h after taking levodopa and lasting a few hours. Accordingly, a repeated levodopa challenge showed that FoG resolved with either levodopa administration or STN stimulation alone, but the combination of both therapies induced recurrence of FoG in our patient. Subsequent management was complex requiring adjustments in levodopa dose and formulation along with advanced DBS programming.
第一作者机构：[1]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China,
通讯作者：
通讯机构：[1]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China,[5]Department of Neurology, Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United States
推荐引用方式(GB/T 7714)：
Shanshan Mei,Jiping Li,Erik H. Middlebrooks,et al.New Onset On-Medication Freezing of Gait After STN-DBS in Parkinson's Disease.[J].Frontiers in neurology.2019,10:659.doi:10.3389/fneur.2019.00659.
APA：
Shanshan Mei,Jiping Li,Erik H. Middlebrooks,Leonardo Almeida,Wei Hu...&Piu Chan.(2019).New Onset On-Medication Freezing of Gait After STN-DBS in Parkinson's Disease..Frontiers in neurology,10,
MLA：
Shanshan Mei,et al."New Onset On-Medication Freezing of Gait After STN-DBS in Parkinson's Disease.".Frontiers in neurology 10.(2019):659
