机构：[a]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China神经内科[b]Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China[c]Department of China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China中美神经科学研究所[d]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China神经外科[e]Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, USA
To investigate the risk factors and predictors of outcomes in a cohort of Chinese patients with cerebral venous sinus thrombosis (CVST), so as to provide a reference for customized clinical decision.
A total of 243 Chinese patients, diagnosed as a first CVST were enrolled in this retrospective study from March 2013 through April 2017. Risk factors and predictors of outcomes for CVST were summarized and analyzed by Chi-square test and logistic regression analysis.
Of the 243 cases, obstetric cause (19.8%) was the leading risk factor for CVST, followed by infection (17.7%) and anemia (17.7%). Gender differences in the risk factors for CVST were analyzed, showing that obstetric cause was the top risk factor in female, while hyperhomocysteinemia (22.3%) was the top risk factor in male. In age subgroups, obstetric cause (26.3%) and anemia (17.6%) were more commonly observed in age?≤?44 years and age?>?44 years subgroup, respectively. The ratio of poor outcomes (mRS?=?3-6) in this cohort was 23.0%, and central nervous system (CNS) infection was closely related to poor outcomes at discharge (p?=?0.023).
The predominant risk factor for CVST, in this Chinese cohort, may still be obstetric cause in female and hyperhomocysteinemia in male. In addition, CNS infection may predict poor outcomes in CVST patients.
Copyright ? 2019 Elsevier B.V. All rights reserved.
第一作者机构：[a]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China[b]Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
通讯作者：
通讯机构：[a]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China[*1]Xuanwu Hospital, Capital Medical University, Beijing, China[b]Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China[c]Department of China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Liqun Pan,Jiayue Ding,Jingyuan Ya,et al.Risk factors and predictors of outcomes in 243 Chinese patients with cerebral venous sinus thrombosis: A retrospective analysis.[J].Clinical neurology and neurosurgery.2019,183:105384.doi:10.1016/j.clineuro.2019.105384.
APA：
Liqun Pan,Jiayue Ding,Jingyuan Ya,Da Zhou,Yanyu Hu...&Ran Meng.(2019).Risk factors and predictors of outcomes in 243 Chinese patients with cerebral venous sinus thrombosis: A retrospective analysis..Clinical neurology and neurosurgery,183,
MLA：
Liqun Pan,et al."Risk factors and predictors of outcomes in 243 Chinese patients with cerebral venous sinus thrombosis: A retrospective analysis.".Clinical neurology and neurosurgery 183.(2019):105384
