机构：[1]Department of Medicine Division of Geriatric Medicine and Gerontology, School of Medicine, Johns Hopkins University, 2024 E. Monument Street, Suite 2-700, Baltimore, MD 21205, USA[2]Center on Aging and Health, Johns Hopkins Medical Institutions, Baltimore, MD, USA[3]Department of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China老年医学科首都医科大学宣武医院[4]The Center of Gerontology and Geriatrics (National Clinical Research Center for Geriatrics), West China Hospital, Sichuan University, Chengdu, China[5]Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
Purpose of ReviewThis review elucidates the concept of frailty in relationship to reserve and resilience, the relationships and shared pathophysiology between physical frailty and cognitive impairment, the theoretical underpinnings of three integrated phenotypes of physical and cognitive impairments, and the potential of incorporating biomarkers into phenotype refinement and validation.Recent FindingsThe fact that frailty and cognitive impairment are associated and often coexist in older adults has led to the popular view of expanding the definition of frailty to include cognitive impairment. However, there is great variability in approaches to and assumptions regarding the integrated phenotypes of physical frailty and cognitive impairment.SummaryThe development of integrated frailty and cognitive phenotypes should explicate the types of frailty and cognitive impairment they intend to capture and prioritize the incorporation of biological theories that help determine shared and distinct pathways in the progression to physical and cognitive impairments.
语种：
外文
被引次数：
WOS：
第一作者：
第一作者机构：[1]Department of Medicine Division of Geriatric Medicine and Gerontology, School of Medicine, Johns Hopkins University, 2024 E. Monument Street, Suite 2-700, Baltimore, MD 21205, USA[2]Center on Aging and Health, Johns Hopkins Medical Institutions, Baltimore, MD, USA
通讯作者：
推荐引用方式(GB/T 7714)：
Xue Qian-Li,Buta Brian,Ma Lina,et al.Integrating Frailty and Cognitive Phenotypes: Why, How, Now What?[J].CURRENT GERIATRICS REPORTS.2019,8(2):97-106.doi:10.1007/s13670-019-0279-z.
APA：
Xue, Qian-Li,Buta, Brian,Ma, Lina,Ge, Meiling&Carlson, Michelle.(2019).Integrating Frailty and Cognitive Phenotypes: Why, How, Now What?.CURRENT GERIATRICS REPORTS,8,(2)
MLA：
Xue, Qian-Li,et al."Integrating Frailty and Cognitive Phenotypes: Why, How, Now What?".CURRENT GERIATRICS REPORTS 8..2(2019):97-106
