Objective To evaluate the safety and feasibility of Angiojet thrombus aspiration combined with stenting angioplasty in treating axillary - subclavian vein thrombosis. Methods Angiojet thrombus aspiration combined with stenting angioplasty was adopted to treat deep vein thrombosis of left upper limb in a 59 - year - old male. After thrombus aspiration with a reduction in thrombus load, stent implantation at the residual stenotic site was carried out. After the treatment, the axillary-subclavian vein flow was unobstructed. Results After the treatment, the left upper limb swelling disappeared, and no procedure-related complications occurred. Reexamination of venous ultrasound at 12 months after the treatment showed that the implanted stent was unobstructed. Conclusion For the treatment of axillary-subclavian vein thrombosis, Angiojet thrombus aspiration combined with stenting angioplasty is safe and feasible, although more number of clinical treatment cases and long-term observations are need before its clinical value can be clarified. © 2019 Publishing House of the Journal of Interventional. All rights reserved.