机构：[1]Department of Vascular Surgery, the Second Affiliated Hospital of Soochow University, Suzhou 215000, China[2]Department of General Surgery, the Fourth Affiliated Hospital of Anhui Medical University, Hefei 230022, China
Deep vein thrombosis (DVT) is a common complication of surgery. Endothelial progenitor cells (EPCs) are recruited into resolving venous thrombi. In this report, we investigated the effects of miR-126 on EPCs function and venous thrombus resolution. We demonstrated that overexpression of miR-126 enhanced EPCs' migration and tubulogenic activity in vitro, and promoted EPCs' homing and thrombus resolving in vivo. Moreover, we identified that miR-126 directly targeted PIK3R2 and affected PI3K/Akt signaling axis. Overall, our findings demonstrated that miR-126 promoted EPCs function through suppressing PIK3R2 expression and modulation of miR-126 may represent a potential therapeutic intervention for treating DVT. J. Cell. Biochem. 116: 1613-1623, 2015. (c) 2015 Wiley Periodicals, Inc.
基金：
Grant sponsor: National Natural Science Foundation of China; Grant numbers: 81400345, 30972941; Grant sponsor:
Jiangsu Provincial Health Department0s Medical Science Program; Grant number: H201211; Grant sponsor: Science and
Technology Innovation Program of Suzhou Science Institution; Grant number: SYS201234; Grant sponsor: Suzhou
City0s Young Scientific Talent Program; Grant number: KJXW2013014; Grant sponsor: Graduate Research and
Innovation Program in Colleges and Universities of Jiangsu Province; Grant numbers: CX2211-0121, CXLX12-0840;
Grant sponsor: Innovation Program of Anhui Medical University; Grant number: 2015xkj043
第一作者机构：[1]Department of Vascular Surgery, the Second Affiliated Hospital of Soochow University, Suzhou 215000, China
通讯作者：
通讯机构：[*1]Department of Vascular Surgery, the Second Affiliated Hospital of Soochow University, No. 1055, Sanxiang Rd., Suzhou 215000, Jiangsu, China.
推荐引用方式(GB/T 7714)：
Qingyou Meng,Wenbin Wang,Xiaobin Yu,et al.Upregulation of MicroRNA-126 Contributes to Endothelial Progenitor Cell Function in Deep Vein Thrombosis via Its Target PIK3R2[J].JOURNAL OF CELLULAR BIOCHEMISTRY.2015,116(8):1613-23.doi:10.1002/jcb.25115.
APA：
Qingyou Meng,Wenbin Wang,Xiaobin Yu,Wendong Li,Lingshang Kong...&Xiaoqiang Li.(2015).Upregulation of MicroRNA-126 Contributes to Endothelial Progenitor Cell Function in Deep Vein Thrombosis via Its Target PIK3R2.JOURNAL OF CELLULAR BIOCHEMISTRY,116,(8)
MLA：
Qingyou Meng,et al."Upregulation of MicroRNA-126 Contributes to Endothelial Progenitor Cell Function in Deep Vein Thrombosis via Its Target PIK3R2".JOURNAL OF CELLULAR BIOCHEMISTRY 116..8(2015):1613-23
