机构：[1]Department of Radiology and Biomedical Imaging, UCSF, San Francisco, California, USA[2]Department of Radiology, Changhai Hospital, Shanghai, China[3]Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Disease, Beijing, China医技科室医学影像科首都医科大学附属安贞医院[4]Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing, China重点科室医技科室研究所放射科北京市神经外科研究所首都医科大学附属天坛医院
Background Intraluminal thrombus (ILT) signal intensity on MRI has been studied as a potential marker of abdominal aortic aneurysm (AAA) progression. Purpose 1) To characterize the relationship between ILT signal intensity and AAA diameter; 2) to evaluate ILT change over time; and 3) to assess the relationship between ILT features and AAA growth. Study Type Prospective. Subjects Eighty AAA patients were imaged, and a subset (n = 41) were followed with repeated MRI for 16 +/- 9 months. Field Strength/Sequence 3D black-blood fast-spin-echo sequence at 3 T. Assessment ILT was designated as "bright" if the signal was greater than 1.2 times that of adjacent psoas muscle. AAAs were divided into three groups based on ILT: Type 1: bright ILT; Type 2: isointense ILT; Type 3: no ILT. During follow-up, an active ILT change was defined as new ILT formation or an increase in ILT signal intensity to bright; stable ILT was defined as no change in ILT type or ILT became isointense from bright previously. Statistical Tests Shapiro-Wilk test; Mann-Whitney U-test; Fisher's exact test; Kruskal-Wallis test; Spearman's r; intraclass correlation coefficient (ICC), Cohen's kappa. Results AAAs with Type 1 ILT were larger than those with Types 2 and 3 ILT (5.1 +/- 1.1 cm, 4.4 +/- 0.9 cm, 4.2 +/- 0.8 cm, P = 0.008). The growth rate of AAAs with Type 1 ILT was significantly greater than that of AAAs with Types 2 and 3 ILT (2.6 +/- 2.5, 0.6 +/- 1.3, 1.5 +/- 0.6 mm/year, P = 0.01). During follow-up, AAAs with active ILT changes had a 3-fold increased growth rate compared with AAAs with stable ILT (3.6 +/- 3.0 mm/year vs. 1.2 +/- 1.5 mm/year, P = 0.008). Data Conclusion AAAs with bright ILT are larger in diameter and grow faster. Active ILT change is associated with faster AAA growth. Black-blood MRI can characterize ILT features and monitor their change over time, which may provide new insights into AAA risk assessment. Technical Efficacy Stage: 5 J. Magn. Reson. Imaging 2019;50:994-1001.
基金：
NHLBI NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Heart Lung & Blood Institute (NHLBI) [K99HL136883, R01HL123759, R01HL114118]
第一作者机构：[1]Department of Radiology and Biomedical Imaging, UCSF, San Francisco, California, USA[*1]Department of Radiology and Biomedical Imaging, 4150 Clement St., San Francisco, CA 94121.
通讯作者：
通讯机构：[1]Department of Radiology and Biomedical Imaging, UCSF, San Francisco, California, USA[2]Department of Radiology, Changhai Hospital, Shanghai, China[*1]Department of Radiology and Biomedical Imaging, 4150 Clement St., San Francisco, CA 94121.[*2]Department of Radiology, Changhai Hospital, 168 Changhai Road, Shanghai, 200433, China.
推荐引用方式(GB/T 7714)：
Zhu Chengcheng,Leach Joseph R.,Tian Bing,et al.Evaluation of the distribution and progression of intraluminal thrombus in abdominal aortic aneurysms using high-resolution MRI[J].JOURNAL OF MAGNETIC RESONANCE IMAGING.2019,50(3):994-1001.doi:10.1002/jmri.26676.
APA：
Zhu, Chengcheng,Leach, Joseph R.,Tian, Bing,Cao, Lizhen,Wen, Zhaoying...&Hope, Michael D..(2019).Evaluation of the distribution and progression of intraluminal thrombus in abdominal aortic aneurysms using high-resolution MRI.JOURNAL OF MAGNETIC RESONANCE IMAGING,50,(3)
MLA：
Zhu, Chengcheng,et al."Evaluation of the distribution and progression of intraluminal thrombus in abdominal aortic aneurysms using high-resolution MRI".JOURNAL OF MAGNETIC RESONANCE IMAGING 50..3(2019):994-1001
