Abdominal aortic aneurysm (AAA) is a fatal disease defined as an abdominal aortic diameter of 3.0 cm or more, where the abdominal aorta exceeds the normal diameter by more than 50%. Histopathological changes of AAA mainly include extracellular matrix (ECM) remodeling at the abdominal aorta wall, but there is lack of specific drugs to treat AAA. Recent studies have reported that lysosomal cathepsins could induce vascular remodeling and AAA formation by regulating vascular inflammation, medial smooth muscle cell apoptosis, neovascularization, and protease expression. Thus, cathepsins are expected to become a new therapeutic target for AAA treatment.
基金:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81100222, 81270389, 81170283]; Program for Changjiang Scholars and Innovative Research Team in UniversitySichuan UniversityProgram for Changjiang Scholars & Innovative Research Team in University (PCSIRT) [IRT1074]; International Science & Technology Cooperation Program of China [2010DFB30040]; Program for New Century Excellent Talents in UniversityProgram for New Century Excellent Talents in University (NCET) [NCET-11-0899]; Scientific Research Common Program of Beijing Municipal Commission of EducationBeijing Municipal Commission of Education [SQKM201210025017]
语种:
外文
WOS:
PubmedID:
第一作者:
第一作者机构:[1]Capital Med Univ, Beijing An Zhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, Key Lab Remodeling Related Cardiovasc Dis,Minist, Beijing 100029, Peoples R China
通讯作者:
通讯机构:[1]Capital Med Univ, Beijing An Zhen Hosp, Beijing Inst Heart Lung & Blood Vessel Dis, Key Lab Remodeling Related Cardiovasc Dis,Minist, Beijing 100029, Peoples R China
推荐引用方式(GB/T 7714):
Wang Yi,Tang Chaoshu,Qin Yanwen.Cathepsins: a new culprit behind abdominal aortic aneurysm[J].REGENERATIVE MEDICINE RESEARCH.2013,1(1):-.doi:10.1186/2050-490X-1-5.
APA:
Wang, Yi,Tang, Chaoshu&Qin, Yanwen.(2013).Cathepsins: a new culprit behind abdominal aortic aneurysm.REGENERATIVE MEDICINE RESEARCH,1,(1)
MLA:
Wang, Yi,et al."Cathepsins: a new culprit behind abdominal aortic aneurysm".REGENERATIVE MEDICINE RESEARCH 1..1(2013):-