Trop2 plays a cardioprotective role by promoting cardiac c-kit(+) cell proliferation and inhibition of apoptosis in the acute phase of myocardial infarction
Trop2 is a cell-surface glycoprotein associated with epithelial carcinomas. Although recent studies indicated that Trop2 is expressed in some stem-like cells, the molecular function of the protein remains largely unknown. In the present study, we observed that acute phase myocardial infarction (MI) induced an increase of c-ki(+)/Trop2(+) cells and found that Trop2 enhanced cardiac c-kit(+) cell survival and proliferation via its antiapoptotic activity, due to an elevated activity of ribosomal S6 kinases in the mitogen-activated protein kinase pathway. This study provides insight into better understanding the molecular function of Trop2, which could serve as a potential target for the treatment of MI.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [30571840]; Specialized Research Fund for the Doctoral Program of Higher EducationSpecialized Research Fund for the Doctoral Program of Higher Education (SRFDP) [20110142110009]
第一作者机构：[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Cardiovasc Surg, Wuhan 430022, Hubei, Peoples R China;[3]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Cardiothorac Surg, Wuhan 430030, Hubei, Peoples R China;
通讯作者：
通讯机构：[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Cardiovasc Surg, Wuhan 430022, Hubei, Peoples R China;[4]Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Cardiovasc Surg, 1277 Jiangan Rd, Wuhan 430022, Hubei, Peoples R China
推荐引用方式(GB/T 7714)：
Yang Jianye,Zhou Yuan,Liu Bo,et al.Trop2 plays a cardioprotective role by promoting cardiac c-kit(+) cell proliferation and inhibition of apoptosis in the acute phase of myocardial infarction[J].INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE.2013,31(6):1298-1304.doi:10.3892/ijmm.2013.1332.
APA：
Yang, Jianye,Zhou, Yuan,Liu, Bo,Wang, Hongfei&Du, Xinling.(2013).Trop2 plays a cardioprotective role by promoting cardiac c-kit(+) cell proliferation and inhibition of apoptosis in the acute phase of myocardial infarction.INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,31,(6)
MLA：
Yang, Jianye,et al."Trop2 plays a cardioprotective role by promoting cardiac c-kit(+) cell proliferation and inhibition of apoptosis in the acute phase of myocardial infarction".INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 31..6(2013):1298-1304
