机构：[1]Zhengzhou Univ, Acad Med Sci, Sch Basic Med Sci, Natl Ctr Int Res Cell & Gene Therapy, Zhengzhou, Peoples R China;[2]Nanjing Univ, Model Anim Res Ctr, Nanjing, Jiangsu, Peoples R China;[3]Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiol, Beijing, Peoples R China;临床科室心脏内科中心首都医科大学附属安贞医院[4]40 Daxue Rd,Two Seven Dist, Zhengzhou, Peoples R China
Previous studies have demonstrated a significantly lower level of Hand1 in ischemic cardiomyopathy than in normal heart tissue. The role of decreased Hand1 in myocardial infarction remains unclear. This study was designed to investigate the effects of haploinsufficiency of Hand1 on mouse heart after myocardial infarction. 8-10 weeks old male heterozygous Hand1-deficient (Hand1(+/-)) mice and wild-type littermates (control) were subjected to sham operation or ligation of the left anterior descending coronary artery to induce acute myocardial infarction (AMI). Hand1(+/-) mice have low incidence of left ventricular free wall rupture in the first week after operation than control mice. Then we found lower MMP9 activity and less cardiomyocytes apoptosis in Hand1(+/-) than in control mice. All of these contribute to the protection role of haploinsufficiency of Hand1 after AMI. (C) 2016 Elsevier Inc. All rights reserved.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [31301007, 81370291]
第一作者机构：[1]Zhengzhou Univ, Acad Med Sci, Sch Basic Med Sci, Natl Ctr Int Res Cell & Gene Therapy, Zhengzhou, Peoples R China;[2]Nanjing Univ, Model Anim Res Ctr, Nanjing, Jiangsu, Peoples R China;
通讯作者：
通讯机构：[1]Zhengzhou Univ, Acad Med Sci, Sch Basic Med Sci, Natl Ctr Int Res Cell & Gene Therapy, Zhengzhou, Peoples R China;[2]Nanjing Univ, Model Anim Res Ctr, Nanjing, Jiangsu, Peoples R China;[4]40 Daxue Rd,Two Seven Dist, Zhengzhou, Peoples R China
推荐引用方式(GB/T 7714)：
Lu Shuangshuang,Du Pan,Shan Congjia,et al.Haploinsufficiency of Hand1 improves mice survival after acute myocardial infarction through preventing cardiac rupture[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2016,478(4):1726-1731.doi:10.1016/j.bbrc.2016.09.012.
APA：
Lu, Shuangshuang,Du, Pan,Shan, Congjia,Wang, Yaohe,Ma, Changsheng&Dong, Jianzeng.(2016).Haploinsufficiency of Hand1 improves mice survival after acute myocardial infarction through preventing cardiac rupture.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,478,(4)
MLA：
Lu, Shuangshuang,et al."Haploinsufficiency of Hand1 improves mice survival after acute myocardial infarction through preventing cardiac rupture".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 478..4(2016):1726-1731
