机构：[1]Emergency & Critical Care Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China临床科室急诊危重症中心首都医科大学附属安贞医院[2]Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China首都医科大学附属安贞医院
Background/AimsCardiac rupture (CR) is a catastrophic complication of acute myocardial infarction (MI). At present, there are no effective pharmacological strategies for preventing post-MI rupture. Here we investigated the effect of trimetazidine (TMZ) on post-MI CR. MethodsMI models were induced by left coronary artery ligation in male C57BL/6 mice. Animals allocated to the rupture incidence were closely monitored for 7days; autopsy was performed once animals were found dead to determine the reason of death. Heart function was detected by echocardiography. Oxidative stress markers and matrix metalloproteinases (MMPs) were analyzed by Western Blotting. ResultsTMZ markedly reduced the post-MI CR incidence of mice. We found that the expression of metalloproteinase (MMP) -2 and MMP-9 in the TMZ-treated group was significantly lower than the saline-treated group. Further, TMZ markedly attenuated MI-induced oxidative stress. To investigate the mechanism of the effect of TMZ on CR, we pretreated H9c2 cells with H2O2 and found that TMZ treatment markedly decreased H2O2-induced MMP-2 and MMP-9 expression. TMZ prevents CR through inhibition of oxidative stress, which is attributable to the down-regulation of MMP-2, MMP-9 expression. ConclusionsOur findings indicate that TMZ suppresses oxidative stress, inhibits MMP-2 and MMP-9 expression, and prevents CR in mice with MI.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81600213, 81670222]; Cardiac Rehabilitation and Metabolic Therapy Research Fund; Capital's Funds for Health Improvement and Research [2018-1-2061]; Capital Medical University Foundation-clinical Research Cooperation Fund [16JL17]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区医学
小类|3 区药学4 区心脏和心血管系统
最新[2023]版：
大类|4 区医学
小类|3 区药学4 区心脏和心血管系统
JCR分区：
出版当年[2016]版：
Q2PHARMACOLOGY & PHARMACYQ2CARDIAC & CARDIOVASCULAR SYSTEMS
第一作者机构：[1]Emergency & Critical Care Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China[2]Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China
通讯作者：
通讯机构：[1]Emergency & Critical Care Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China[2]Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China[*1]Emergency & Critical Care Center, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Road, Chaoyang District, Beijing 100029, China
推荐引用方式(GB/T 7714)：
Gong Wei,Ma Youcai,Li Aobo,et al.Trimetazidine suppresses oxidative stress, inhibits MMP-2 and MMP-9 expression, and prevents cardiac rupture in mice with myocardial infarction[J].CARDIOVASCULAR THERAPEUTICS.2018,36(5):-.doi:10.1111/1755-5922.12460.
APA：
Gong, Wei,Ma, Youcai,Li, Aobo,Shi, Han&Nie, Shaoping.(2018).Trimetazidine suppresses oxidative stress, inhibits MMP-2 and MMP-9 expression, and prevents cardiac rupture in mice with myocardial infarction.CARDIOVASCULAR THERAPEUTICS,36,(5)
MLA：
Gong, Wei,et al."Trimetazidine suppresses oxidative stress, inhibits MMP-2 and MMP-9 expression, and prevents cardiac rupture in mice with myocardial infarction".CARDIOVASCULAR THERAPEUTICS 36..5(2018):-
