机构：[1]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantanxili, Beijing 100050, China重点科室诊疗科室神经外科神经外科首都医科大学附属天坛医院[2]Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou 215123, China神经外科普外科苏州大学附属第二医院[3]China National Clinical Research Center for Neurological Diseases, Beijing 100050, China[4]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases, Beijing 100050, China[5]Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China研究所北京市神经外科研究所首都医科大学附属天坛医院[6]Department of Neurosurgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, China
Abdominal aortic aneurysms (AAAs) and intracranial saccular aneurysms (IAs) are the most common types of aneurysms. This study was to investigate the common pathogenesis shared between these two kinds of aneurysms. We collected 12 IAs samples and 12 control arteries from the Beijing Tiantan Hospital and performed microarray analysis. In addition, we utilized the microarray datasets of IAs and AAAs from the Gene Expression Omnibus (GEO), in combination with our microarray results, to generate messenger RNA expression profiles for both AAAs and IAs in our study. Functional exploration and protein-protein interaction (PPI) analysis were performed. A total of 727 common genes were differentially expressed (404 was upregulated; 323 was downregulated) for both AAAs and IAs. The GO and pathway analyses showed that the common dysregulated genes were mainly enriched in vascular smooth muscle contraction, muscle contraction, immune response, defense response, cell activation, IL-6 signaling and chemokine signaling pathways, etc. The further protein-protein analysis identified 35 hub nodes, including TNF, IL6, MAPK13, and CCL5. These hub node genes were enriched in inflammatory response, positive regulation of IL-6 production, chemokine signaling pathway, and T/B cell receptor signaling pathway. Our study will gain new insight into the molecular mechanisms for the pathogenesis of both types of aneurysms and provide new therapeutic targets for the patients harboring AAAs and IAs.
基金：
This research was supported by the following
funds: Cooperative project between The Science and Technology
Ministry of China and Canada titled “Research on the genetics and pathogenesis
of intracranial aneurysm and arteriovenous malformation,” led
by Professor Jizong Zhao (No. 2010dfb30850); Beijing Municipal
Administration of Hospitals’ Mission Plan (SML20150501); “11th
Five-Year Plan” the National Science and Technology supporting plan
(2006BAI01A13); “13th Five-Year Plan” National Science and
Technology supporting plan (2015BAI09B04); the National Key
Technology Research and Development Program of the Ministry of
Science and Technology of China (2013BAI09B03); and “973” the
Ministry of Science and Technology of China (2012CB825505).
第一作者机构：[1]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantanxili, Beijing 100050, China[2]Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou 215123, China[3]China National Clinical Research Center for Neurological Diseases, Beijing 100050, China[4]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases, Beijing 100050, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantanxili, Beijing 100050, China[2]Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou 215123, China[3]China National Clinical Research Center for Neurological Diseases, Beijing 100050, China[4]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases, Beijing 100050, China
推荐引用方式(GB/T 7714)：
Wen Wang,Hao Li,Zheng Zhao,et al.The pathogenesis shared between abdominal aortic aneurysms and intracranial aneurysms: a microarray analysis[J].NEUROSURGICAL REVIEW.2018,41(2):667-674.doi:10.1007/s10143-017-0912-2.
APA：
Wen Wang,Hao Li,Zheng Zhao,Haoyuan Wang,Dong Zhang...&Jizong Zhao.(2018).The pathogenesis shared between abdominal aortic aneurysms and intracranial aneurysms: a microarray analysis.NEUROSURGICAL REVIEW,41,(2)
MLA：
Wen Wang,et al."The pathogenesis shared between abdominal aortic aneurysms and intracranial aneurysms: a microarray analysis".NEUROSURGICAL REVIEW 41..2(2018):667-674
：