机构：[1]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China[2]Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, China[3]Beijing Neurosurgical Institute, Capital Medical University, Beijing, China[4]China National Clinical Research Center for Neurological Diseases, Beijing, China[5]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases, Beijing, China[6]Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China
Intracranial aneurysm (IA) is pathological dilatations of the cerebral artery and rupture of IAs can cause subarachnoid hemorrhage, which has a high ratio of fatality and morbidity. However, the pathogenesis of IAs remains unknown. We performed long noncoding RNA (lncRNA) and messenger RNA (mRNA) expression profiles in IA tissues and superficial temporal arteries (STAs). A total of 4129 differentially expressed lncRNAs and 2926 differentially expressed mRNAs were obtained from the microarrays (P < 0.05). Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses showed that up-regulated mRNAs were enriched in immune response, inflammatory response, regulation of immune response and lysosome, et al; while the down-regulated mRNAs were enriched in muscle contraction, smooth muscle contraction, cGMP-PKG signaling pathway and vascular smooth muscle contraction, et al. The lncRNA-mRNA co-expression networks were represented in immune response, inflammatory response, muscle contraction and vascular smooth muscle contraction. These findings may gain insight in the pathogenesis of IAs and provide clues to find key roles for IA patients.
基金：
This work was supported by grants from National High Technology Research and Development Program (No. 2012AA02A508), the “13th Five-Year Plan” National Science and Technology supporting plan (No. 2015BAI09B04).
第一作者机构：[1]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China[2]Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, China[4]China National Clinical Research Center for Neurological Diseases, Beijing, China[5]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China[2]Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, China[4]China National Clinical Research Center for Neurological Diseases, Beijing, China[5]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases, Beijing, China
推荐引用方式(GB/T 7714)：
Wen Wang,Hao Li,Lanbing Yu,et al.Aberrant expression of lncRNAs and mRNAs in patients with intracranial aneurysm[J].ONCOTARGET.2017,8(2):2477-2484.doi:10.18632/oncotarget.13908.
APA：
Wen Wang,Hao Li,Lanbing Yu,Zheng Zhao,Haoyuan Wang...&Jizong Zhao.(2017).Aberrant expression of lncRNAs and mRNAs in patients with intracranial aneurysm.ONCOTARGET,8,(2)
MLA：
Wen Wang,et al."Aberrant expression of lncRNAs and mRNAs in patients with intracranial aneurysm".ONCOTARGET 8..2(2017):2477-2484
医学