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LncAPC drives Wnt/β-catenin activation and liver TIC self-renewal through EZH2 mediated APC transcriptional inhibition

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收录情况： ◇ SCIE

作者：

机构： [1]Department of Histology and Embryology, College of Basic Medicine, Zhengzhou University, Henan, China [2]Department of Cancer Biology Immunotherapy, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou University, Henan, China [3]Department of Otolaryngology, Medical School, University of Minnesota, Twin Cities Campus, Minneapolis, Minnesota [4]Department of Pathology, School of Medicine, University of Virginia, Virginia [5]Department of Nuclear Medicine, The Affiliated Beijing Anzhen Hospital of Capital Medical University, Capital Medical University, Beijing, China [6]Department of Hepatopancreatobiliary Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou University, Henan, China

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关键词： liver cancer long noncoding RNA remodeling complex tumor initiating cells Wnt/β-catenin

摘要：

Liver tumor initiating cells (TICs), a small subset cells in tumor bulk, are responsible for liver tumor initiation, metastasis, and relapse. However, the regulatory mechanism of liver TICs remains largely unknown. Here we found a long noncoding RNA lncAPC, locating near from APC locus, was highly expressed in liver cancer and liver TICs. LncAPC was required for liver TIC self-renewal. Silencing and overexpressing lncAPC showed impaired and enhanced sphere formation capacity of liver TICs, respectively. By recruiting EZH2 to APC promoter, LncAPC inhibits APC transcription and thus drives the activation of Wnt/β-catenin signaling. Attenuate binding between EZH2 and APC promoter was observed upon lncAPC knockdown. What is more, lncAPC-EZH2-APC axis can be targeted to eliminate liver TICs. Altogether, LncAPC promotes liver TIC self-renewal through EZH2-dependent APC transcriptional inhibition. © 2017 Wiley Periodicals, Inc.

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出版当年[2017]版：

大类 | 2 区医学

小类 | 2 区生化与分子生物学 2 区肿瘤学

最新[2023]版：

大类 | 2 区医学

小类 | 2 区生化与分子生物学 3 区肿瘤学

JCR分区：

出版当年[2016]版：

Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q2 ONCOLOGY

最新[2023]版：

Q2 ONCOLOGY Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

影响因子： 3 最新[2023版] 3.8 最新五年平均 4.185 出版当年[2016版] 4.021 出版当年五年平均 4.722 出版前一年[2015版] 3.851 出版后一年[2017版]

第一作者：

第一作者机构： [1]Department of Histology and Embryology, College of Basic Medicine, Zhengzhou University, Henan, China [2]Department of Cancer Biology Immunotherapy, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou University, Henan, China

通讯作者：

通讯机构： [1]Department of Histology and Embryology, College of Basic Medicine, Zhengzhou University, Henan, China [*1]Department of Histology and Embryology, College of Basic Medicine, Zhengzhou University, 100 Kexue Road, Zhengzhou, Henan 450052, China

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LncAPC drives Wnt/β-catenin activation and liver TIC self-renewal through EZH2 mediated APC transcriptional inhibition

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