详情页 - 首都医科大学宣武医院知识库

当前位置：首页 > 详情页

Genetic variance of transforming growth factor β2 gene in conotruncal heart defects

文献详情

资源类型：

收录情况： ◇ SCIE

作者：

机构： [a]Department of Cardiology, Sichuan Academy of Medical Sciences, Sichuan Provincial People’s Hospital, Chengdu, China [b]Department of Cardiology, Hospital of the University of Electronic Science and Technology of China, Chengdu, China [c]Department of Cardiovascular Surgery, West China Hospital of Sichuan University, Chengdu, China [d]Department of Cardiovascular Surgery, The Seventh People’s Hospital of Chengdu, Chengdu, China [e]Department of Cardiology, West China Hospital of Sichuan University, Chengdu610041, China [f]Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, China [g]Department of Cardiovascular Surgery Center, Beijing An-Zhen Hospital, Capital Medical University, Beijing, China

出处：

DOI：

ISSN：

关键词： Conotruncal heart defects single nucleotide polymorphisms transforming growth factor β2

摘要：

Objective: The aim of this study was to evaluate the association between two haplotype-tag single nucleotide polymorphisms (SNPs) (rs6658835 and rs10495098) of TGF-β2 and conotruncal heart defects (CTDs). Methods: Two polymorphisms of TGF-β2 gene were genotyped by polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) from 259 CTDs patients and 310 control subjects. Results: The association between SNP rs6658835 in TGF-β2 and CTDs has been found. The frequency of G allele in CTDs patients was significantly higher than that in control subjects (52.7% versus 40.3%, p < 0.001, OR =1.649). Conclusion:TGF-β2 gene polymorphisms may serve as a novel genetic marker for the risk of CTDs. © 2016 Informa UK Limited, trading as Taylor & Francis Group.

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2016]版：

大类 | 3 区医学

小类 | 3 区生物工程与应用微生物 3 区毒理学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区生物工程与应用微生物 4 区毒理学

JCR分区：

出版当年[2015]版：

Q3 TOXICOLOGY Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

最新[2023]版：

Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q4 TOXICOLOGY

影响因子： 2 最新[2023版] 2.3 最新五年平均 2.016 出版当年[2015版] 2.12 出版当年五年平均 2.26 出版前一年[2014版] 2.006 出版后一年[2016版]

第一作者：

第一作者机构： [a]Department of Cardiology, Sichuan Academy of Medical Sciences, Sichuan Provincial People’s Hospital, Chengdu, China [b]Department of Cardiology, Hospital of the University of Electronic Science and Technology of China, Chengdu, China

共同第一作者：

通讯作者：

通讯机构： [e]Department of Cardiology, West China Hospital of Sichuan University, Chengdu610041, China

推荐引用方式(GB/T 7714)：

APA：

MLA：

Genetic variance of transforming growth factor β2 gene in conotruncal heart defects

文献详情

相关文献