Aim: Racial differences and genetic overlap have been shown to be responsible for the difference in susceptibility to dermatomyositis (DM)/polymyositis (PM) in a variety of populations. Single nucleotide polymorphisms (SNPs) in the GLI-similar 3 (GLIS3) and tyrosine kinase 2 (TYK2) genes have been associated with various autoimmune diseases. The aim of this study was to investigate whether SNPs in GLIS3 (rs7020673, rs10758593, and rs10814916) and TYK2 (rs280519, rs2304256, rs17000730, and rs280501) were associated with an increase in susceptibility to DM/PM in a Chinese Han population. Materials and Methods: SNPs in GLIS3 and TYK2 were analyzed in a cohort of 1017 patients with DM/PM and 1280 healthy controls using a Sequenom MassArray system. Association analyses were performed using the PLINK v1.07 software. Results: In our study, the GLIS3 polymorphisms rs7020673 and rs10758593 were initially found to be predisposing risk factors for PM and PM with interstitial lung disease (p < 0.05). Both rs7020673 and rs10758593 were associated with PM in both additive and dominant models (p < 0.05); however, these observed associations were not apparent after Bonferroni correction. Other SNPs examined in our study were not associated with susceptibility to DM/PM. Conclusion: GLIS3 and TYK2 polymorphisms are not associated with DM/PM in the Chinese Han population. As associations of SNPs in these genes in patients with DM/PM have been previously reported in other populations, we may conclude that the lack of association in our study may be the result of differences in genetic background. Further studies in other populations are needed to confirm our findings.
基金:
Research Special Fund for Public Welfare Industry of Health [201202004]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81172857, 81373188]; Chinese National High Technology Research and Development Program, Ministry of Science and TechnologyNational High Technology Research and Development Program of China [2011AA02A113]; National Science Technology Pillar Program in the 12nd Five-year Plan [2014BAI07B00]; Capital Health Research and Development of Special [2014-1-4011]
第一作者机构:[1]Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Rheumatol & Clin Immunol, 1 Shuaifuyuan, Beijing 100730, Peoples R China;[2]Minist Educ, Peking Union Med Coll, Key Lab Rheumatol & Clin Immunol, 1 Shuaifuyuan, Beijing 100730, Peoples R China;
通讯作者:
通讯机构:[1]Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Rheumatol & Clin Immunol, 1 Shuaifuyuan, Beijing 100730, Peoples R China;[2]Minist Educ, Peking Union Med Coll, Key Lab Rheumatol & Clin Immunol, 1 Shuaifuyuan, Beijing 100730, Peoples R China;
推荐引用方式(GB/T 7714):
Li Liubing,Chen Si,Wang Qian,et al.GLIS3 and TYK2 Single Nucleotide Polymorphisms Are Not Associated with Dermatomyositis/Polymyositis in Chinese Han Population[J].GENETIC TESTING AND MOLECULAR BIOMARKERS.2017,21(9):565-570.doi:10.1089/gtmb.2017.0059.
APA:
Li, Liubing,Chen, Si,Wang, Qian,Wu, Chanyuan,Wen, Xiaoting...&Li, Yongzhe.(2017).GLIS3 and TYK2 Single Nucleotide Polymorphisms Are Not Associated with Dermatomyositis/Polymyositis in Chinese Han Population.GENETIC TESTING AND MOLECULAR BIOMARKERS,21,(9)
MLA:
Li, Liubing,et al."GLIS3 and TYK2 Single Nucleotide Polymorphisms Are Not Associated with Dermatomyositis/Polymyositis in Chinese Han Population".GENETIC TESTING AND MOLECULAR BIOMARKERS 21..9(2017):565-570