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Association between the BANK1 rs3733197 polymorphism and polymyositis/dermatomyositis in a Chinese Han population

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收录情况： ◇ SCIE

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机构： [1]Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China [2]Department of Clinical Laboratory, Beijing Anzhen Hospital, Capital Medical University, Beijing, China [3]Department of Rheumatology and Clinical Immunology, Peking Union Medical College and Chinese Academy of Medical Sciences, No. 1 Shuai Fu Yuan, Eastern District, Beijing 100730, China

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关键词： Association BANK1 Dermatomyositis Polymyositis rs3733197

摘要：

The aim of our study was to investigate the association between single nucleotide polymorphisms (SNPs) in the BANK1 gene and polymyositis/dermatomyositis (PM/DM) in a Chinese Han population. In total, 363 PM patients, 654 DM patients, and 1280 healthy controls were recruited and genotyped using the Sequenom MassArray system. A significant allele association was observed in rs3733197 among the PM/DM patients (OR 0.81, 95%CI 0.70-0.94, Pc = 1.83 x 10(-2)). Notably, rs3733197 was associated with DM and PM/DM patients with ILD involvement (Pc = 0.026; Pc = 6.0 x 10(-3), respectively). However, no statistically significant difference was observed in the allele or genotype frequencies of three SNPs (rs4522865, rs17266594, and rs10516487) among the DM, PM, and PM/DM patients and healthy controls (all Pc > 0.05). This study was the first to demonstrate that a BANK1 gene SNP (rs3733197) could confer genetic predisposition in PM/DM patients and PM/DM patients with ILD in a Chinese Han population.

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出版当年[2018]版：

大类 | 4 区医学

小类 | 4 区风湿病学

最新[2025]版：

大类 | 3 区医学

小类 | 4 区风湿病学

JCR分区：

出版当年[2017]版：

Q3 RHEUMATOLOGY

最新[2023]版：

Q2 RHEUMATOLOGY

影响因子： 2.9 最新[2023版] 2.8 最新五年平均 2.141 出版当年[2017版] 2.1 出版当年五年平均 2.365 出版前一年[2016版] 2.293 出版后一年[2018版]

第一作者：

第一作者机构： [1]Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China [2]Department of Clinical Laboratory, Beijing Anzhen Hospital, Capital Medical University, Beijing, China

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通讯作者：

通讯机构： [1]Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China [3]Department of Rheumatology and Clinical Immunology, Peking Union Medical College and Chinese Academy of Medical Sciences, No. 1 Shuai Fu Yuan, Eastern District, Beijing 100730, China

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