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Pediatric hematopoietic stem cell transplantation in China: Data and trends during 1998-2012.

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收录情况： ◇ SCIE

作者：

机构： [1]Navy General Hospital, Beijing, China, [2]Shanghai Children’s Medical Center, Shanghai, China, [3]Beijing Children’s Hospital, Beijing, China, [4]Second Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China, [5]Prince of Wales Hospital, Hong Kong, China, [6]West China Second University Hospital of Sichuan University, Chengdu, China, [7]Guangzhou Women and Children Medical Center, Guangzhou, China, [8]Beijing Tongren Hospital, Beijing, China, [9]Children’s Hospital of Chongqing Medical University, Chongqing, China, [10]Zhe Jiang University School of Medicine Children Hospital, Hangzhou, China, [11]Soochow University Affiliated Children’s Hospital, Suzhou, China, [12]Capital Institute of Pediatics, Beijing, China, [13]Wuhan Union Hospital, Wuhan, China

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关键词： hematopoietic stem cell transplantation cord blood survival graft-versus-host disease

摘要：

The success of treating a wide variety of pediatric diseases with HSCT, hematologic malignancies in particular, has resulted in an increased number of long-term survivors. This study is the first large-scale, multicentre report that describes the evolution of pediatric HSCTs in China during the period of 1998-2012. Of all 1052 patients, 266 cases were treated with autologous HSCs and 786 used allogeneic HSCs. The disease indications for HSCTs mainly included leukemias, lymphoma, solid tumors, and non-malignant disorders. The total number of HSCTs, especially unrelated donor transplants, appeared to be increasing year by year. For patients with neuroblastoma, the therapeutic efficacy seemed to be poor, with a five-yr OS and DFS rate of 34.5 ± 14.3% and 20.7 ± 9.6%, respectively. In contrast, the survival of patients with SAA was prominently improved, and their five-yr OS and DFS rates were 82.8 ± 4% and 80.7 ± 4.1%, respectively. Patients who received cord blood transplants had a lower incidence of acute GVHD than that of PB and/or BM transplants from unrelated donors. This report offers us a valuable resource for evaluating the changes in HSCTs in China over the past 14 yr. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

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中科院(CAS)分区：

出版当年[2014]版：

大类 | 4 区医学

小类 | 3 区儿科 4 区移植

最新[2023]版：

大类 | 4 区医学

小类 | 4 区儿科 4 区移植

JCR分区：

出版当年[2013]版：

Q2 PEDIATRICS Q3 TRANSPLANTATION

最新[2023]版：

Q3 PEDIATRICS Q3 TRANSPLANTATION

影响因子： 1.2 最新[2023版] 1.5 最新五年平均 1.63 出版当年[2013版] 1.544 出版当年五年平均 1.5 出版前一年[2012版] 1.441 出版后一年[2014版]

第一作者：

第一作者机构： [1]Navy General Hospital, Beijing, China,

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通讯作者：

通讯机构： [1]Navy General Hospital, Beijing, China, [*1]Department of Pediatrics, Navy General Hospital, No. 6, Fucheng Road, Beijing 100048, China

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Pediatric hematopoietic stem cell transplantation in China: Data and trends during 1998-2012.

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