机构：[1]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 Southern 4th Ring Road West, Fengtai District, Beijing 100070, China重点科室诊疗科室神经外科神经外科首都医科大学附属天坛医院[2]China National Clinical Research Center for Neurological Diseases, Beijing 100070, China[3]Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100050, China[4]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing 100070, China
Brain arteriovenous malformations (AVMs) near/within eloquent areas are challenging to treat surgically. The insufficient lesion-to-eloquence distance (LED) is related to poor neurological outcomes. This paper reports the use of in situ embolization combined with surgical resection in a one-staged hybrid operation for eloquent area protection. Nine patients who underwent one-staged in situ embolization combined with surgical resection were selected from the database of a prospective clinical trial (NCT03774017). Nidus got partial in situ embolization in the parts located near/within the eloquence. The rest of nidus was removed via a microsurgical procedure in the same operation. The in situ embolization ensured a sufficient LED to prevent eloquent areas and tracts from being damaged in the subsequent resection. All of the patients achieved complete obliteration with no neurological deficits or complications. One-staged hybrid operation initiates closer cooperation between surgical and endovascular treatments and proposes an integrative therapeutic mode for AVMs. The in situ embolization combined with surgical resection is safe and effective for improving the functional outcome of AVMs with eloquence and tracts involved. The clinical trial is registered at (NCT03774017, ).
基金：
Beijing Science and Planning Project [D161100003816005]; Key Technologies Research and Development Program [2016YFC1301800]
第一作者机构：[1]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 Southern 4th Ring Road West, Fengtai District, Beijing 100070, China[2]China National Clinical Research Center for Neurological Diseases, Beijing 100070, China[3]Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100050, China[4]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing 100070, China
通讯作者：
通讯机构：[1]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 Southern 4th Ring Road West, Fengtai District, Beijing 100070, China[2]China National Clinical Research Center for Neurological Diseases, Beijing 100070, China[3]Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100050, China[4]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing 100070, China
推荐引用方式(GB/T 7714)：
Wang Mingze,Qiu Hancheng,Cao Yong,et al.One-staged in situ embolization combined with surgical resection for eloquence protection of AVM: technical note[J].NEUROSURGICAL REVIEW.2019,42(3):783-790.doi:10.1007/s10143-019-01137-w.
APA：
Wang, Mingze,Qiu, Hancheng,Cao, Yong,Wang, Shuo&Zhao, Jizong.(2019).One-staged in situ embolization combined with surgical resection for eloquence protection of AVM: technical note.NEUROSURGICAL REVIEW,42,(3)
MLA：
Wang, Mingze,et al."One-staged in situ embolization combined with surgical resection for eloquence protection of AVM: technical note".NEUROSURGICAL REVIEW 42..3(2019):783-790
