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Gene Expression Profiling of Two Epilepsy Models Reveals the ECM/Integrin signaling Pathway is Involved in Epiletogenesis

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收录情况： ◇ SCIE

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机构： [a]Department of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China [b]Beijing Key Laboratory of Neuromodulation, Beijing Municipal Science and Technology Commission, Beijing 100050, China [c]Department of Neurosurgery, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, China [d]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China [e]Department of Neurology, University of Florida, FL 32607, USA

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关键词： epilepsy extracellular matrix integrins neuron death astrocyte activation

摘要：

The molecular mechanisms underlying the development of epilepsy, i.e., epileptogenesis, are due to altered expression of a series of genes. Global expression profiling of temporal lobe epilepsy is confounded by a number of factors, including the variability among animal species, animal models, and tissue sampling time-points. In this study, we pooled two microarray datasets of the most used pilocarpine and kainic acid epilepsy models from the Gene Expression Omnibus database. A total of 567 known and novel genes were commonly differentially expressed across the two models. Pathway analyses demonstrated that the dysregulated genes were involved in 46 pathways. Real-time PCR and western blot analysis confirmed the activation of extracellular matrix (ECM)/integrin signaling pathways. Moreover, targeting ECM/integrin signaling inhibits astrocyte activation and promotes neuron injury in the hippocampus of epileptic mice. This study may provide a "gene/pathway database" that with further investigation can determine the mechanisms underlining epileptogenesis and the possible targets for neuron protection in the hippocampus after status epilepticus. (C) 2018 IBRO. Published by Elsevier Ltd. All rights reserved.

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出版当年[2018]版：

大类 | 3 区医学

小类 | 3 区神经科学

最新[2023]版：

大类 | 3 区医学

小类 | 4 区神经科学

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出版当年[2017]版：

Q2 NEUROSCIENCES

最新[2023]版：

Q2 NEUROSCIENCES

影响因子： 2.9 最新[2023版] 3 最新五年平均 3.382 出版当年[2017版] 3.362 出版当年五年平均 3.277 出版前一年[2016版] 3.244 出版后一年[2018版]

第一作者：

第一作者机构： [a]Department of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China [b]Beijing Key Laboratory of Neuromodulation, Beijing Municipal Science and Technology Commission, Beijing 100050, China

通讯作者：

通讯机构： [a]Department of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China [b]Beijing Key Laboratory of Neuromodulation, Beijing Municipal Science and Technology Commission, Beijing 100050, China [*1]Beijing Neurosurgical Institute, Capital Medical University, No. 6 TiantanXili, Dongcheng District, Beijing 100050, China.

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Gene Expression Profiling of Two Epilepsy Models Reveals the ECM/Integrin signaling Pathway is Involved in Epiletogenesis

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