机构：[1]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing重点科室诊疗科室神经外科神经外科首都医科大学附属天坛医院[2]China National Clinical Research Center for Neurological Diseases, Beijing, China
OBJECTIVE: We sought to clarify the expression characteristics and prognostic significance of transforming growth factor (TGF)-beta 3 in cranial meningiomas. METHODS: We analyzed the expression of TGF-beta 3 at the mRNA level in 38 frozen meningioma samples. Clinical data collection, follow-up, correlations, and survival analyses were performed. RESULTS: World Health Organization (WHO) grade I meningiomas showed an average expression level of 2.55, which was higher than that of WHO grade II (average of 1.50) and WHO grade III (average of 0.21) (Kruskal-Wallis test, P = 0.008). For meningiomas with a history of surgery, the mean TGF-beta 3 expression level was 0.71, much lower than that of primary meningiomas with a mean value of 2.55 (Mann-Whitney U-test, P = 0.008). According to the Kaplan-Meier analysis and univariate Cox analysis, WHO grade (P = 0.001), history of surgery (P < 0.001), tumor volume (P = 0.045), preoperative Karnofsky Performance Status (P = 0.001), peritumoral brain edema (P = 0.039), postoperative radiotherapy (P = 0.001), degree of resection (P = 0.039), and TGF-beta 3 expression (P = 0.038) were prognostic factors for tumor recurrence. In addition, WHO grade (P < 0.001), history of surgery (P < 0.001), preoperative Karnofsky Performance Status (P = 0.002), peritumoral brain edema (P = 0.006), postoperative radiotherapy (P = 0.007), bone invasion (P = 0.03), and TGF-beta 3 expression (P = 0.041) were prognostic factors for mortality. CONCLUSIONS: TGF-beta 3 expression levels gradually declined with the increase of WHO grade and were lower in recurrent meningiomas than in primary meningiomas. Besides, low TGF-beta 3 expression was found to predict tumor recurrence and mortality in meningiomas based on univariate analysis.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81672506, 81872052, 81472370]; Outstanding Talent Training Projects Foundation of Beijing [2017000021469G261, 2017000021469G259]
第一作者机构：[1]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing[2]China National Clinical Research Center for Neurological Diseases, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing[2]China National Clinical Research Center for Neurological Diseases, Beijing, China
推荐引用方式(GB/T 7714)：
Ma Junpeng,Li Da,Chen Yujia,et al.Low Transforming Growth Factor-beta 3 Expression Predicts Tumor Malignancy in Meningiomas[J].WORLD NEUROSURGERY.2019,125:E353-E360.doi:10.1016/j.wneu.2019.01.077.
