机构：[1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China重点科室诊疗科室神经病学中心神经病学中心首都医科大学附属天坛医院[2]Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China[3]Department of Neurology, Kailuan General Hospital, North China University of Science and Technology, Tangshan, China[4]Graduate School, North China University of Science and Technology, Tangshan, China[5]Department of Cardiology, Kailuan General Hospital, North China University of Science and Technology, Tangshan, China[6]Department of Cardiology, Tangshan People’s Hospital, North China University of Science and Technology, Tangshan, China[7]Department of Geriatric Disease, Kailuan General Hospital, North China University of Science and Technology, Tangshan, China
In this study we tested whether vascular aging is associated with the risk of first stroke in the Kailuan cohort, a community-based Chinese cohort. For participants aged >= 50 years, healthy vascular aging (HVA) was defined as an absence of hypertension and a brachial-ankle pulse wave velocity < the mean + 2 standard deviations, which was determined from a reference sample of healthy participants aged < 30 years. The primary outcome was first stroke (ischemic or hemorrhagic). In total, 11,474 participants were enrolled. The prevalence of HVA decreased from 36.0% in participants aged 50-59 years to 4.7% in those aged >= 70 years. During a median follow-up of 3.3 years, the incidence of first stroke was 0.5% in the HVA group but was 2.6% in the Non-HVA group. After adjusting for confounding variables, HVA was associated with a 0.32-fold lower risk of first stroke compared to the Non-HVA group (95% confidence interval, 0.18-0.56; p < 0.001). It thus appears that HVA reduced the risk of first stroke in a community-based Chinese population. This suggests that evaluation of vascular aging as part of public health screening may be useful for stroke risk assessment.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81825007]; Ministry of Science and Technology of the People's Republic of ChinaMinistry of Science and Technology, China [2017YFC1307900]; Beijing Municipal Education Commission (Excellent Young Scientists Project); third batch of National Ten Thousand Talents Plan; Young Elite Scientists Sponsorship Program by CAST [2018QNRC001]; Beijing Municipal Science and Technology Commission (Beijing Excellent Talents Training and Supporting Top Youth Team) [D171100003017001, 2016000021223TD03]
第一作者机构：[1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China[2]Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China[2]Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China[5]Department of Cardiology, Kailuan General Hospital, North China University of Science and Technology, Tangshan, China
推荐引用方式(GB/T 7714)：
Yang Yingying,Wang Anxin,Yuan Xiaodong,et al.Association between healthy vascular aging and the risk of the first stroke in a community-based Chinese cohort[J].AGING-US.2019,11(15):5807-5816.doi:10.18632/aging.102170.
APA：
Yang, Yingying,Wang, Anxin,Yuan, Xiaodong,Zhao, Quanhui,Liu, Xiaoxue...&Wang, Yilong.(2019).Association between healthy vascular aging and the risk of the first stroke in a community-based Chinese cohort.AGING-US,11,(15)
MLA：
Yang, Yingying,et al."Association between healthy vascular aging and the risk of the first stroke in a community-based Chinese cohort".AGING-US 11..15(2019):5807-5816
