机构：[1]Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing重点科室诊疗科室神经外科神经外科首都医科大学附属天坛医院[2]China National Clinical Research Center for Neurological Diseases, Beijing[3]Beijing Key Laboratory of Central Nervous System Injury, Beijing[4]Neurotrauma Laboratory, Beijing Neurosurgical Institute, Capital Medical University, Beijing研究所北京市神经外科研究所首都医科大学附属天坛医院[5]Department of Neurosurgery, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou[6]Nerve Injury and Repair Center of Beijing Institute for Brain Disorders, Beijing, People’s Republic of China
OBJECTIVE: Although several prognostic factors for traumatic brain injury (TBI) have been evaluated, a useful predictive scoring model for the outcomes has not been developed for patients with severe TBI who undergo decompressive craniectomy (DC). The aim of the present study was to determine independent predictors and develop a multivariate logistic regression equation to predict the early outcome and discharge status for patients with severe TBI who have undergone DC. METHODS: A total of 13 different variables were evaluated. The data from all 278 patients with severe TBI who had undergone DC in the present study were retrospectively evaluated from July 2011 to June 2017. Using univariate, multiple logistic regression and prognostic regression scoring equations it was possible to draw receiver operating characteristic curves to predict the early outcomes and discharge status after TBI. RESULTS: We found that younger age (P = 0.012), no significant medical history (P = 0.044), diameter of both pupils < 4 mm (P = 0.032), higher admission Glasgow coma scale score (P = 0.004), no tracheotomy (P < 0.001), and DC for severe TBI were associated with a favorable early outcome and discharge status. Using receiver operating characteristic curves to predict the probability of a favorable outcome, the sensitivity was 80.0% and the specificity was 79.5%. CONCLUSIONS: Our preliminary findings have shown that 5 variables can be used as independent predictors in assessing the early outcome and discharge status for patients with severe TBI after DC.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81801225, 81171144, 81471238]; Natural Science Foundation of Capital Medical University [PYZ2017075]; Youth Foundation of Beijing Tian Tan Hospital [2017-YQN-03]
第一作者机构：[1]Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing[2]China National Clinical Research Center for Neurological Diseases, Beijing[3]Beijing Key Laboratory of Central Nervous System Injury, Beijing[4]Neurotrauma Laboratory, Beijing Neurosurgical Institute, Capital Medical University, Beijing
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing[2]China National Clinical Research Center for Neurological Diseases, Beijing[3]Beijing Key Laboratory of Central Nervous System Injury, Beijing[4]Neurotrauma Laboratory, Beijing Neurosurgical Institute, Capital Medical University, Beijing[6]Nerve Injury and Repair Center of Beijing Institute for Brain Disorders, Beijing, People’s Republic of China
推荐引用方式(GB/T 7714)：
Tian Runfa,Liu Weiming,Dong Jinqian,et al.Prognostic Predictors of Early Outcomes and Discharge Status of Patients Undergoing Decompressive Craniectomy After Severe Traumatic Brain Injury[J].WORLD NEUROSURGERY.2019,126:E101-E108.doi:10.1016/j.wneu.2019.01.246.
APA：
Tian, Runfa,Liu, Weiming,Dong, Jinqian,Zhang, Ji,Xu, Long...&Liu, Baiyun.(2019).Prognostic Predictors of Early Outcomes and Discharge Status of Patients Undergoing Decompressive Craniectomy After Severe Traumatic Brain Injury.WORLD NEUROSURGERY,126,
MLA：
Tian, Runfa,et al."Prognostic Predictors of Early Outcomes and Discharge Status of Patients Undergoing Decompressive Craniectomy After Severe Traumatic Brain Injury".WORLD NEUROSURGERY 126.(2019):E101-E108
