Comparison of early and late decompressive craniectomy on the long-term outcome in patients with moderate and severe traumatic brain injury: a meta-analysis
机构：[a]Department of General Surgery, the Second Affiliated Hospital of Soochow University, Soochow, Jiangsu, P.R. China[b]Department of Hepatobiliary Surgery, the Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, P.R. China[c]Department of Anesthesiology, the Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, P.R. China[d]Central Laboratory, the Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, P.R. China
Background Several studies have searched whether early decompressive craniectomy (DC) can improve the long-term outcome of patients with moderate and severe traumatic brain injury (TBI). However, the effects of early DC remain unclear. The purpose of this meta-analysis was to assess whether early DC (time to surgery after injury<24h) is better than late DC (>24h) after moderate and severe TBI. Method Two reviewers independently searched Pubmed, Embase, ISI web of science, the Cochrane Library and Scopus databases from inception to 4 November 2014. Studies comparing the long-term outcome of patients following early and late DC after TBI were included. The long-term outcomes were evaluated by Glasgow Outcome Score, Extended Glasgow Outcome Score. Newcastle-Ottawa Scale was used to assess the methodological quality of included studies. Characteristics of the selected studies were extracted. Pooled results were presented by odds ratios (ORs) with 95% CIs. I-2 was used to test heterogeneity. Pearson correlation coefficient was used to detect the relationship between bilateral pupil abnormality and unfavourable outcome. Results Five articles were eligible for this meta-analysis. The pooled results of comparison of unfavourable outcome and mortality revealed no significant difference in the early and late groups (ORs: 1.469; 95% CIs: 0.495-4.362; p>0.05; I-2=70.5% and ORs: 1.262; 95% CIs: 0.385-4.137; p>0.05; I-2=77.6%, respectively). Pearson correlation coefficient indicated that bilateral pupil abnormality was positive related to the unfavourable outcomes and mortality (r=0.833; p<0.05) (0.829; p<0.05). Conclusion Bilateral pupil abnormality is positive related to unfavourable outcome and mortality in the patients following DC after moderate and severe TBI. Early DC may be more helpful to improve the long-term outcome of patients with refractory raised intracranial cerebral pressure after moderate and severe TBI. However, more RCTs with better control of patients with bilateral pupil abnormality divided into the early and late groups are needed in the future.
基金：
This work was supported by Fund of Science and Technology of
Yixing (2014-14), and Fund of Six Best Talent of Jiangsu (WSN-025).
第一作者机构：[a]Department of General Surgery, the Second Affiliated Hospital of Soochow University, Soochow, Jiangsu, P.R. China[b]Department of Hepatobiliary Surgery, the Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, P.R. China
共同第一作者：
通讯作者：
通讯机构：[*1]The Second Affiliated Hospital of Soochow University, No. 1055 Sanxiang Road, Soochow, Jiangsu 215004, P.R. China
推荐引用方式(GB/T 7714)：
Kai Zhang,Wenjie Jiang,Tieliang Ma,et al.Comparison of early and late decompressive craniectomy on the long-term outcome in patients with moderate and severe traumatic brain injury: a meta-analysis[J].BRITISH JOURNAL OF NEUROSURGERY.2016,30(2):251-7.doi:10.3109/02688697.2016.1139052.
APA：
Kai Zhang,Wenjie Jiang,Tieliang Ma&Haorong Wu.(2016).Comparison of early and late decompressive craniectomy on the long-term outcome in patients with moderate and severe traumatic brain injury: a meta-analysis.BRITISH JOURNAL OF NEUROSURGERY,30,(2)
MLA：
Kai Zhang,et al."Comparison of early and late decompressive craniectomy on the long-term outcome in patients with moderate and severe traumatic brain injury: a meta-analysis".BRITISH JOURNAL OF NEUROSURGERY 30..2(2016):251-7
