Decompressive craniectomy protects against hippocampal edema and behavioral deficits at an early stage of a moderately controlled cortical impact brain injury model in adult male rats
机构：[a]Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing, 100050, PR China重点科室诊疗科室神经外科神经外科首都医科大学附属天坛医院[b]China National Clinical Research Center for Neurological Diseases, Beijing, 100050, PR China[c]Beijing Key Laboratory of Central Nervous System Injury, Beijing, 100050, PR China[d]Department of Diagnostics, Clinical College, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, PR China[e]Department of Neurosurgery, Baoan District Central Hospital, Shenzhen, 518102, PR China[f]Department of Neurosurgery, The First Affiliated Hospital of Anhui Medical University, Hefei, 230000, PR China[g]Neurotrauma Laboratory, Beijing Neurosurgical Institute, Capital Medical University, Beijing, 100050, PR China研究所北京市神经外科研究所首都医科大学附属天坛医院[h]Nerve Injury and Repair Center of Beijing Institute for Brain Disorders, Beijing, 100050, PR China
A decompressive craniectomy (DC) has been shown to be a life-saving therapeutic treatment for traumatic brain injury (TBI) patients, which also might result in post-operative behavioral dysfunction. However, there is still no definite conclusion about whether the behavioral dysfunction already existed at an early stage after the DC operation or is just a long-term post-operation complication. Therefore, the aim of the present study was to analyze whether DC treatment was beneficial to behavioral function at an early stage post TBI. In this study, we established a controlled cortical impact injury rat model to evaluate the therapeutic effect of DC treatment on behavioral deficits at 1 d, 2 d, 3 d and 7 d after TBI, Our results showed that rats suffered significant behavioral and mood deficits after TBI compared to the control group, while decompressive craniectomy treatment could normalize MMP-9 expression levels and reduce hippocampal edema formation, stabilize the expression of Synapsin I, which was a potential indicator of maintaining the hippocampal synaptic function, thus counteracting behavioral but not mood decay in rats subjected to TBI. In conclusion, decompressive craniectomy, excepting for its life-saving effect, could also play a potential beneficial neuroprotective role on behavioral but not mood deficits at an early stage of moderate traumatic brain injury in rats.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81471238]; National Key Technology Research and Development Program of the Ministry of Science and Technology of ChinaNational Key Technology R&D Program [2013BAI09B03]; Beijing Institute for Brain Disorders [BIBD-PXM2013_014226_07_000084]
第一作者机构：[a]Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing, 100050, PR China[b]China National Clinical Research Center for Neurological Diseases, Beijing, 100050, PR China[c]Beijing Key Laboratory of Central Nervous System Injury, Beijing, 100050, PR China
共同第一作者：
通讯作者：
通讯机构：[a]Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing, 100050, PR China[b]China National Clinical Research Center for Neurological Diseases, Beijing, 100050, PR China[c]Beijing Key Laboratory of Central Nervous System Injury, Beijing, 100050, PR China[e]Department of Neurosurgery, Baoan District Central Hospital, Shenzhen, 518102, PR China[g]Neurotrauma Laboratory, Beijing Neurosurgical Institute, Capital Medical University, Beijing, 100050, PR China[h]Nerve Injury and Repair Center of Beijing Institute for Brain Disorders, Beijing, 100050, PR China[*1]Neurotrauma Laboratory, Beijing Neurosurgical Institute, and Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Tiantan Xili 6, Dongcheng District, Beijing, 100050, PR China.[*2]Department of Neurosurgery, Baoan District Central Hospital, Xiyuan Street 6, Baoan District, Shenzhen, 518102, PR China.
推荐引用方式(GB/T 7714)：
Zonggang Hou,Runfa Tian,Feifei Han,et al.Decompressive craniectomy protects against hippocampal edema and behavioral deficits at an early stage of a moderately controlled cortical impact brain injury model in adult male rats[J].BEHAVIOURAL BRAIN RESEARCH.2018,345:1-8.doi:10.1016/j.bbr.2018.02.010.
APA：
Zonggang Hou,Runfa Tian,Feifei Han,Shuyu Hao,Weichuan Wu...&Baiyun Liu.(2018).Decompressive craniectomy protects against hippocampal edema and behavioral deficits at an early stage of a moderately controlled cortical impact brain injury model in adult male rats.BEHAVIOURAL BRAIN RESEARCH,345,
MLA：
Zonggang Hou,et al."Decompressive craniectomy protects against hippocampal edema and behavioral deficits at an early stage of a moderately controlled cortical impact brain injury model in adult male rats".BEHAVIOURAL BRAIN RESEARCH 345.(2018):1-8
