机构：[1]Department of Neurology, Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Capital Medical University, Beijing, China,重点科室诊疗科室神经病学中心神经病学中心首都医科大学附属天坛医院[2]School of Computer and Information Technology, Beijing Jiaotong University, Beijing, China,[3]Department of Nuclear Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,医技科室核医学科首都医科大学附属天坛医院[4]Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Medicine, Beihang University, Beijing, China
Objective: The purpose of this study is to evaluate the potential diagnostic benefit of SPM-based semi-quantitative FDG-PET analysis in autoimmune encephalitis (AE) compared with visual analysis by experienced neuroradiologists using a larger sample size. Methods: This observational retrospective case series study was conducted from a tertiary epilepsy center between May 2014 and March 2017. Healthy individuals without any neurologic or psychiatric diseases were recruited as control. We determined brain FDG-PET abnormal glucose metabolism on medial temporal lobe and basal ganglia using semi-quantitative analysis and compared this method with visual analysis at the same time among patients with autoantibody positive AE. Results: Twenty-eight patients with clinically diagnosed AE and 53 healthy individuals without any neurologic or psychiatric diseases were recruited. On the medial temporal lobe and the basal ganglia, semi-quantitative analysis showed consistency with the visual assessment for whom they had abnormal metabolism by visual assessment. More importantly, 56% patients on medial temporal lobe and 73% patients on the basal ganglia respectively who were not identified by visual inspection can be detected by semi-quantitative analysis, demonstrating the greater sensitivity of semi-quantitative analysis compared with visual assessment. Significance: This study showed semi-quantitative brain FDG-PET analysis was better than visual analysis in view of observing the abnormal glucose metabolism of patients with autoantibody positive AE. Semi-quantitative FDG-PET analysis appears to be a helpful tool in early diagnosis of patients with AE.
基金：
Application Research of Capital Clinical Characteristics [Z181100001718082]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [61673051, 61375110, 81301119]; Beijing Municipal Administration of Hospitals' Youth Programme [QML20160504]; China Association Against Epilepsy-UCB Research Fund [CAAE-UCB2016008]; Natural Science Foundation of Capital Medical University [PYZ2017055]
第一作者机构：[1]Department of Neurology, Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Capital Medical University, Beijing, China,
通讯作者：
通讯机构：[2]School of Computer and Information Technology, Beijing Jiaotong University, Beijing, China,[3]Department of Nuclear Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,[4]Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Medicine, Beihang University, Beijing, China
推荐引用方式(GB/T 7714)：
Rui-Juan Lv,Jian Pan,Guifei Zhou,et al.Semi-quantitative FDG-PET Analysis Increases the Sensitivity Compared With Visual Analysis in the Diagnosis of Autoimmune Encephalitis[J].FRONTIERS IN NEUROLOGY.2019,10(JUN):-.doi:10.3389/fneur.2019.00576.
APA：
Rui-Juan Lv,Jian Pan,Guifei Zhou,Qun Wang,Xiao-Qiu Shao...&Jiangang Liu.(2019).Semi-quantitative FDG-PET Analysis Increases the Sensitivity Compared With Visual Analysis in the Diagnosis of Autoimmune Encephalitis.FRONTIERS IN NEUROLOGY,10,(JUN)
MLA：
Rui-Juan Lv,et al."Semi-quantitative FDG-PET Analysis Increases the Sensitivity Compared With Visual Analysis in the Diagnosis of Autoimmune Encephalitis".FRONTIERS IN NEUROLOGY 10..JUN(2019):-
