机构：[1]Chinese Acad Med Sci, Dept Neurol, Peking Union Med Coll Hosp, Beijing 100730, Peoples R China;[2]Henan Prov Peoples Hosp, Dept Neurol, Zhengzhou 450003, Henan, Peoples R China;[3]Chinese Acad Med Sci, Dept Dermatol, Peking Union Med Coll Hosp, Beijing 100730, Peoples R China;[4]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R China重点科室诊疗科室神经病学中心神经病学中心首都医科大学附属天坛医院
The autoimmune encephalitis can develop with or without an underlying tumor. For tumor-negative auto immune encephalitis, the causes are still largely unknown. Here we presented three patients with autoimmune encephalitis accompanied with vitiligo. Among them, two patients suffered from anti-leucine-rich glioma-inactivated 1 (LGI1) encephalitis and one patient suffered from anti-IgLON5 encephalopathy. All of them received intravenous immunoglobulin and steroids as immunotherapy. The two patients with anti-LGI1 encephalitis recovered and got a good prognosis. For the patient with anti-IgLON5 encephalopathy, he only got a moderate and transient improvement. Based on the above, we speculate that vitiligo may be a clue to an autoimmune cause for encephalitis.
