机构：[1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,重点科室诊疗科室神经病学中心神经病学中心首都医科大学附属天坛医院[2]National Center for Clinical Medicine of Neurological Diseases, Beijing, China,[3]Beijing Institute for Brain Disorders, Beijing, China,[4]Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
There is growing evidence that ketone bodies, which are derived from fatty acid oxidation and usually produced in fasting state or on high-fat diets have broad neuroprotective effects. Although the mechanisms underlying the neuroprotective effects of ketone bodies have not yet been fully elucidated, studies in recent years provided abundant shreds of evidence that ketone bodies exert neuroprotective effects through possible mechanisms of anti-oxidative stress, maintaining energy supply, modulating the activity of deacetylation and inflammatory responses. Based on the neuroprotective effects, the ketogenic diet has been used in the treatment of several neurological diseases such as refractory epilepsy, Parkinson's disease, Alzheimer's disease, and traumatic brain injury. The ketogenic diet has great potential clinically, which should be further explored in future studies. It is necessary to specify the roles of components in ketone bodies and their therapeutic targets and related pathways to optimize the strategy and efficacy of ketogenic diet therapy in the future.
基金：
National Key R&D Program of China [2017YFC1307500]; Beijing-Tianjin-Hebei Cooperative Basic Research Program [H2018206435]; Capital Healthy Development Research Funding [2016-1-2011]; Natural Foundation of Capital Medical University [PYZ2017132]; Beijing Key Laboratory on Clinical study of Epilepsy [2016DXBL02]; Center for CNS Drug Discovery
第一作者机构：[1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,[2]National Center for Clinical Medicine of Neurological Diseases, Beijing, China,
通讯作者：
通讯机构：[1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,[2]National Center for Clinical Medicine of Neurological Diseases, Beijing, China,[3]Beijing Institute for Brain Disorders, Beijing, China,[4]Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Huajun Yang,Wei Shan,Fei Zhu,et al.Ketone Bodies in Neurological Diseases: Focus on Neuroprotection and Underlying Mechanisms[J].FRONTIERS IN NEUROLOGY.2019,10(JUN):-.doi:10.3389/fneur.2019.00585.
APA：
Huajun Yang,Wei Shan,Fei Zhu,Jianping Wu&Qun Wang.(2019).Ketone Bodies in Neurological Diseases: Focus on Neuroprotection and Underlying Mechanisms.FRONTIERS IN NEUROLOGY,10,(JUN)
MLA：
Huajun Yang,et al."Ketone Bodies in Neurological Diseases: Focus on Neuroprotection and Underlying Mechanisms".FRONTIERS IN NEUROLOGY 10..JUN(2019):-
