机构：[1]Beijing Neurosurgical Institute, Capital Medical University, 6, Tiantanxili, 100050 Beijing, China研究所北京市神经外科研究所首都医科大学附属天坛医院[2]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China重点科室诊疗科室神经外科神经外科首都医科大学附属天坛医院[3]Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing, China
PurposeThe hand knob area is the cortical representation of motor hand function. The current study aimed to investigate the effects of eloquent area gliomas on the morphometry of the hand motor cortex and preoperative hand motor function.MethodsA retrospective study of 320 glioma patients was conducted. Seventy-eight patients with gliomas involving motor functional area were finally enrolled. Using axial T2-weight magnetic resonance images, the width and height of the hand knob were measured in both hemispheres, and differences were compared between the affected and unaffected hemispheres. Receiver operating characteristic (ROC) curve and logistic regression analysis were used to estimate the degree of correlation between distance measurements and motor impairment.ResultsThe width and height of the hand knob in the affected and unaffected hemispheres were significantly different (p<0.0001). The width, height and distance from the tumor to hand knob were reduced in the functionally impaired group compared to the unimpaired group (p=0.0003, p<0.0001, p=0.0005, respectively). The three parameters were significantly correlated and remained significant in ROC and logistic regression analysis. The optimal cut-off value of width, height and distance for identifying preoperative hand muscle strength were 5.73mm, 5.80mm and 5.92mm, respectively.ConclusionThe morphometry of the hand knob is often changed by the infiltration or extrusion of the tumors that were located in or near the hand knob. The width, height of hand knob and the distance from tumor to hand knob could serve as anatomic biomarkers related to preoperative neurological motor deficits.
基金：
National Key Research and Development Plan [2016YFC0902500]; National High Technology Research and Development ProgramNational High Technology Research and Development Program of China [2015CB 755500]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|3 区医学
小类|3 区临床神经病学3 区核医学
最新[2023]版：
大类|3 区医学
小类|3 区临床神经病学3 区核医学
JCR分区：
出版当年[2017]版：
Q2CLINICAL NEUROLOGYQ2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版：
Q2CLINICAL NEUROLOGYQ2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
第一作者机构：[1]Beijing Neurosurgical Institute, Capital Medical University, 6, Tiantanxili, 100050 Beijing, China[2]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[1]Beijing Neurosurgical Institute, Capital Medical University, 6, Tiantanxili, 100050 Beijing, China[2]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China[3]Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing, China
推荐引用方式(GB/T 7714)：
Liang Jingshan,Fang Shengyu,Fan Xing,et al.Morphometry of the Hand Knob Region and Motor Function Change in Eloquent Area Glioma Patients[J].CLINICAL NEURORADIOLOGY.2019,29(2):243-251.doi:10.1007/s00062-017-0659-8.
APA：
Liang Jingshan,Fang Shengyu,Fan Xing,Wang Zheng,Zhang Chuanbao...&Jiang Tao.(2019).Morphometry of the Hand Knob Region and Motor Function Change in Eloquent Area Glioma Patients.CLINICAL NEURORADIOLOGY,29,(2)
MLA：
Liang Jingshan,et al."Morphometry of the Hand Knob Region and Motor Function Change in Eloquent Area Glioma Patients".CLINICAL NEURORADIOLOGY 29..2(2019):243-251
