个人科研网厅 | | 帮助
首都医科大学宣武医院知识库
高级检索
当前位置： 首页 > 详情页

Diminished cytolytic activity of gamma delta T cells with reduced DNAM-1 expression in neuroblastoma patients

| 认领 | 导出 | |

文献详情

资源类型：

收录情况： ◇ SCIE

作者：
Wang, Xiaolin[1,2,3] * ; Mou, Wenjun[1,2,3] ; Han, Wei[4] ; Xi, Yue[1,2,3] ; Chen, Xi[1,2,3] ; Zhang, Hui[1,2,3] ; Qin, Hong[4] ; Wang, Huanmin[4] ; Ma, Xiaoli[5] ; Gui, Jingang[1,2,3,*1] ;
机构： [1]Key Laboratory of Major Disease in Children, Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China [2]Laboratory of Tumor Immunology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China [3]Beijing Key Laboratory for Genetics of Birth Defects, MOE Key Laboratory of Major Diseases in Children, Center for Medical Genetics, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China [4]Department of Surgical Oncology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China [5]Hematology Oncology Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China
出处：
DOI： 10.1016/j.clim.2019.04.006
ISSN：

关键词： gamma delta T cells Neuroblastoma DNAM-1 Cytolytic activity

摘要：
Neuroblastoma is one of the children's malignant tumors with poor prognosis, as well as high recurrence and metastasis rates after surgical removal and chemotherapy. gamma delta T-cell based immunotherapy receives increasing attention thanks to the strong cytolytic activity to tumor cells. Our previous data revealed a significant increase in circulating gamma delta T-cell frequency in NB patients. In the present study, we found that beside a reduction of IFN-gamma in serum of NB patients, DNAM-1 expression decreased in both circulating and PAM-expanded NB gamma delta T cells. Upon PAM stimulation, NB gamma delta T cells showed a reduced level of cell proliferation. In addition, the cytolytic activity of NB gamma delta T cells to NB cell lines was proved to be attenuated in a co-culture system. The fact that DNAM-1 neutralizing antibody abolished the tumor cell killing accentuates the indispensable role of DNAM-1 molecule in gamma delta T-cell cytolytic function.

基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81772668]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类 | 2 区 医学
小类 | 3 区 免疫学
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 免疫学
JCR分区：
出版当年[2017]版：
Q2 IMMUNOLOGY
最新[2023]版：
Q2 IMMUNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

第一作者：
第一作者机构： [1]Key Laboratory of Major Disease in Children, Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China [2]Laboratory of Tumor Immunology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China [3]Beijing Key Laboratory for Genetics of Birth Defects, MOE Key Laboratory of Major Diseases in Children, Center for Medical Genetics, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China
通讯作者：
通讯机构： [1]Key Laboratory of Major Disease in Children, Ministry of Education, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China [2]Laboratory of Tumor Immunology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China [3]Beijing Key Laboratory for Genetics of Birth Defects, MOE Key Laboratory of Major Diseases in Children, Center for Medical Genetics, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China [*1]Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.
推荐引用方式(GB/T 7714)：
Wang Xiaolin,Mou Wenjun,Han Wei,et al.Diminished cytolytic activity of gamma delta T cells with reduced DNAM-1 expression in neuroblastoma patients[J].CLINICAL IMMUNOLOGY.2019,203:63-71.doi:10.1016/j.clim.2019.04.006.
APA：
Wang, Xiaolin,Mou, Wenjun,Han, Wei,Xi, Yue,Chen, Xi...&Gui, Jingang.(2019).Diminished cytolytic activity of gamma delta T cells with reduced DNAM-1 expression in neuroblastoma patients.CLINICAL IMMUNOLOGY,203,
MLA：
Wang, Xiaolin,et al."Diminished cytolytic activity of gamma delta T cells with reduced DNAM-1 expression in neuroblastoma patients".CLINICAL IMMUNOLOGY 203.(2019):63-71

相关文献

[1]gamma delta TFH cells promote B cell maturation and antibody production in neuroblastoma [2]Deficiency of gamma delta T cells protects against abdominal aortic aneurysms by regulating phosphoinositide 3-kinase/AKT signaling [3]IL-17A produced by both gamma delta T and Th17 cells promotes renal fibrosis via RANTES-mediated leukocyte infiltration after renal obstruction [4]A promising sword of tomorrow: Human gamma delta T cell strategies reconcile allo-HSCT complications [5]Immune Cytolytic Activity Is Associated With Genetic and Clinical Properties of Glioma [6]Ⅳ期高危神经母细胞瘤患儿局部放疗疗效分析 [7]Management of intracranial invasive olfactory neuroblastoma [8]CHROMOSOME ANALYSIS OF NEUROBLASTOMA IN CHILDREN [9]Refractory diarrhea: A paraneoplastic syndrome of neuroblastoma [10]Ectopic Olfactory Neuroblastoma Arising in the Nasopharynx

资源点击量：16409 今日访问量：0 总访问量：869 更新日期：2025-01-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 首都医科大学宣武医院 技术支持：重庆聚合科技有限公司 地址：北京市西城区长椿街45号宣武医院