机构：[1]Department of Pharmacy, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China[2]Department of Pediatric Pharmacology and Pharmacogenetics, H?pital Robert Debré, APHP, Paris, France[3]Neonatal Intensive Care Unit, CHU de Rennes, Rennes, France[4]Precision Cancer Medicine Team, Institut Gustave Roussy, Villejuif, France[5]Clinical Research Center, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China医技科室职能科室临床流行病与循证医学中心临床研究中心首都医科大学附属北京儿童医院[6]Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Shandong University, Jinan, China[7]University Paris Diderot, Sorbonne Paris-Cité, Paris, France
We evaluated the population pharmacokinetics of caspofungin in children (2 to 12 years of age). The real-world data from 48 children were best fit by a two-compartment model with first-order elimination. Subsequent covariate analysis demonstrated that body surface area had a significant correlation with caspofungin pharmacokinetics, compared to body weight. The population pharmacokinetics of caspofungin confirmed that adjustment of caspofungin dosage based on body surface area is most appropriate for pediatric use.
基金：
National Science and Technology Major Project for Major New Drugs Innovation and Development [2017ZX09304029-001, 2017ZX09304029-002]; Shandong University
第一作者机构：[1]Department of Pharmacy, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China
通讯作者：
通讯机构：[1]Department of Pharmacy, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China[2]Department of Pediatric Pharmacology and Pharmacogenetics, H?pital Robert Debré, APHP, Paris, France[6]Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Shandong University, Jinan, China[7]University Paris Diderot, Sorbonne Paris-Cité, Paris, France
推荐引用方式(GB/T 7714)：
Yang Xin-Mei,Leroux Stephanie,Storme Thomas,et al.Body Surface Area-Based Dosing Regimen of Caspofungin in Children: a Population Pharmacokinetics Confirmatory Study[J].ANTIMICROBIAL AGENTS AND CHEMOTHERAPY.2019,63(7):-.doi:10.1128/AAC.00248-19.
APA：
Yang, Xin-Mei,Leroux, Stephanie,Storme, Thomas,Zhang, Dao-Lun,de Beaumais, Tiphaine Adam...&Jacqz-Aigrain, Evelyne.(2019).Body Surface Area-Based Dosing Regimen of Caspofungin in Children: a Population Pharmacokinetics Confirmatory Study.ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,63,(7)
MLA：
Yang, Xin-Mei,et al."Body Surface Area-Based Dosing Regimen of Caspofungin in Children: a Population Pharmacokinetics Confirmatory Study".ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 63..7(2019):-
医学