机构：[1]Department of Medical Microbiology, Capital Medical University, Beijing, China[2]Department of Infectious Diseases, Beijing Children's Hospital, Beijing, China职能科室临床流行病与循证医学中心首都医科大学附属北京儿童医院[3]Department of Medical Microbiology and Immunology, University of Turku, Turku, Finland
Objectives: To evaluate the association of mannose-binding lectin (MBL) deficiency with susceptibility and clinical features of group B Streptococcus (GBS) causing meningitis in Chinese infants. Methods: During 2014-2017, 33 infants with laboratory-confirmed GBS meningitis were included. Six polymorphisms (H/L, Y/X, P/Q, A/D, A/B and A/C) of MBL were sought for in these patients and in 330 healthy controls by PCR-based sequencing. Serum MBL concentration was determined. Results: Significantly higher frequency of MBL variant genotype A/B was found in patients than controls (15/33, 45%, vs. 79/330, 24%, p = 0.011). Patients with variant genotype A/B had significantly lower serum MBL than those with wild-type genotype A/A (median, 482.87 vs. 1455.13 ng/mL, p = 0.002). Moreover, patients with genotype A/B had significantly higher level of C-reactive protein (median, 146 vs. 41 mg/L, p = 0.007), neutrophil (median, 58.1% vs. 45.7%, p = 0.033) and neutrophil-to-lymphocyte ratio in blood (median, 2.32 vs. 1.03, p = 0.018) compared to those with genotype A/A. No significant differences were observed in clinical features of patients with different genotypes. Conclusions: Our result suggested that infants with MBL deficiency are at higher risk of meningitis caused by GBS. Further studies in different populations with larger number of subjects are needed. (c) 2018 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
基金：
Beijing Natural Science FoundationBeijing Natural Science Foundation [7142021]
第一作者机构：[1]Department of Medical Microbiology, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[1]Department of Medical Microbiology, Capital Medical University, Beijing, China[2]Department of Infectious Diseases, Beijing Children's Hospital, Beijing, China[3]Department of Medical Microbiology and Immunology, University of Turku, Turku, Finland[*1]Department of Infectious Diseases, Beijing Children's Hospital, No 56, Nan Li Shi Lu, Xicheng District, Beijing 100045, PR China[*2]Capital Medical University, No. 10 Xi Tou Tiao, You'an Men Wai, Feng Tai District, Beijing 100069, PR China.
推荐引用方式(GB/T 7714)：
Chen N.,Zhang X.,Zheng K.,et al.Increased risk of group B Streptococcus causing meningitis in infants with mannose-binding lectin deficiency[J].CLINICAL MICROBIOLOGY AND INFECTION.2019,25(3):-.doi:10.1016/j.cmi.2018.10.003.
APA：
Chen, N.,Zhang, X.,Zheng, K.,Zhu, L.,Zhang, N....&He, Q..(2019).Increased risk of group B Streptococcus causing meningitis in infants with mannose-binding lectin deficiency.CLINICAL MICROBIOLOGY AND INFECTION,25,(3)
MLA：
Chen, N.,et al."Increased risk of group B Streptococcus causing meningitis in infants with mannose-binding lectin deficiency".CLINICAL MICROBIOLOGY AND INFECTION 25..3(2019):-
医学