机构：[1]Department of Radiation Oncology, Tiantan Hospital, Capital Medical University, Beijing, China.首都医科大学附属天坛医院[2]Department of Radiation Oncology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.[3]Shandong Provincial Key Laboratory of Radiation Oncology, Cancer Research Center, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, China.
As a crucial oncogene, B cell lymphoma-2 (BCL-2) could promote cancer cell survival by inhibiting apoptosis via suppressing activation of proapoptotic proteins, such as BAX and BAK. There is a functional rs2279115 genetic polymorphism locating in BCL-2 promoter and deregulating BCL-2 expression. However, it is still largely undefined how BCL-2 rs2279115 promoter noncoding genetic variant is involved in glioma development. We examined the association between BCL-2 rs2279115 and glioma risk using a case-control approach. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by logistic regression adjusted by age and sex. Our results demonstrated that BCL-2 rs2279115 was significantly associated with glioma risk. The odd of individuals harboring A allele (CA + AA genotype) was 0.50 (95% CI = 0.39-0.64, p = 1.0 x 10(-7)) compared with CC genotype carriers. Stratification analyses by sex elucidated that BCL-2 rs2279115 was significantly associated with glioma risk in males (OR = 0.41, 95% CI = 0.30-0.58, p = 1.0 x 10(-7)), but not in females (p > 0.05). In summary, our results indicate that the functional BCL-2 rs2279115 genetic variant contributes to glioma predisposition and suggest prevalent involvement of regulatory genetic variations in glioma development.
基金：
Capital Health Research Projects [2016-2-1073]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [31671300, 31871306]; Taishan Scholars Program of Shandong Province [tsqn20161060]
第一作者机构：[1]Department of Radiation Oncology, Tiantan Hospital, Capital Medical University, Beijing, China.
共同第一作者：
通讯作者：
通讯机构：[3]Shandong Provincial Key Laboratory of Radiation Oncology, Cancer Research Center, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, China.[*1]Shandong Provincial Key Laboratory of Radiation Oncology, Cancer Research Center, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences,Jinan Shandong Province 250117, China
推荐引用方式(GB/T 7714)：
Qiu Xiao-Guang,Chen Yi-Dong,Yuan Jupeng,et al.Functional BCL-2 rs2279115 Promoter Noncoding Variant Contributes to Glioma Predisposition, Especially in Males[J].DNA AND CELL BIOLOGY.2019,38(1):85-90.doi:10.1089/dna.2018.4318.
APA：
Qiu, Xiao-Guang,Chen, Yi-Dong,Yuan, Jupeng,Zhang, Nasha,Lei, Tianshui...&Yang, Ming.(2019).Functional BCL-2 rs2279115 Promoter Noncoding Variant Contributes to Glioma Predisposition, Especially in Males.DNA AND CELL BIOLOGY,38,(1)
MLA：
Qiu, Xiao-Guang,et al."Functional BCL-2 rs2279115 Promoter Noncoding Variant Contributes to Glioma Predisposition, Especially in Males".DNA AND CELL BIOLOGY 38..1(2019):85-90
