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Overexpression of miR-224-3p alleviates apoptosis from cerebral ischemia reperfusion injury by targeting FIP200

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机构： [1]Departments of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, China [2]China National Clinical Research Center for Neurological Diseases, China [3]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China [4]Central Hospital of Zibo, Department of Neurology, Zibo

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关键词： apoptosis FIP200 ischemic stroke miR-224-3p

摘要：

Aims: In previous studies, numerous differential microRNAs (miRNAs) in cerebral ischemic/reperfusion (I/R) injury were identified using the miRNA microarray analysis. However, the relationship between miRNA and cerebral I/R injury remains largely unknown. In this study, we investigated the function and explored the possible mechanism of miR-224-3p in cerebral I/R injury. Methods: Oxygen glucose deprivation model in N2a cells were used to perform the cerebral I/R injury in vitro. Trypan blue staining, reactive oxygen species (ROS) production, and caspase-3 were measured to evaluate the function of miR-224-3p. Results: Overexpression of miR-224-3p alleviated the apoptosis induced by oxygen glucose deprivation (OGD) and cleaved caspase-3 was significantly reduced. We further provided the possible mechanism that miR-224-3p may protect cells from cerebral I/R injury by targeting FAK family-interacting protein (FIP200). Further rescue experiment proved that overexpression of FIP200 partially blocked the effect of miR-224-3p. Conclusions: We evaluated the function and mechanism of miR-224-3p in ischemic brain injury. miR-224-3p may serve as a potential target for new therapeutic intervention. © 2019 Wiley Periodicals, Inc.

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出版当年[2018]版：

大类 | 3 区生物

小类 | 3 区生化与分子生物学 4 区细胞生物学

最新[2023]版：

大类 | 3 区生物学

小类 | 3 区生化与分子生物学 4 区细胞生物学

JCR分区：

出版当年[2017]版：

Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 CELL BIOLOGY

最新[2023]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 CELL BIOLOGY

影响因子： 3 最新[2023版] 3.1 最新五年平均 2.959 出版当年[2017版] 3.132 出版当年五年平均 3.085 出版前一年[2016版] 3.448 出版后一年[2018版]

第一作者：

第一作者机构： [1]Departments of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, China [2]China National Clinical Research Center for Neurological Diseases, China [3]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China

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通讯作者：

通讯机构： [1]Departments of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, China [2]China National Clinical Research Center for Neurological Diseases, China [3]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China [*1]Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, China,National Clinical Research Center for Neurological Diseases, No. 6 Tiantan Xili, 100050 Beijing, China.

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