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The Third China National Stroke Registry (CNSR-III) for patients with acute ischaemic stroke or transient ischaemic attack: Design, rationale and baseline patient characteristics

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机构: [1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China [2]China National Clinical Research Center for Neurological Diseases, Beijing, China [3]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China [4]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China [5]Department of Neurology, The First people's Hospital of Taizhou, Taizhou, China [6]Department of Neurology, The Kaifeng Central Hospital, Kaifeng, China [7]Department of Neurology, The First People's Hospital of Xi'an, Xi'an, China [8]Department of Neurology, The Second People’s Hospital of Jinzhong, Jinzhong, China [9]Department of Neurology, WuYuan County People’s Hospital, Bayannur, China
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关键词: biomarker outcome registry stroke transient ischaemic attack

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Background and purpose: Stroke is the leading cause of mortality and disability in China. Precise aetiological classification, imaging and biological markers may predict the prognosis of stroke. The Third China National Stroke Registry (CNSR-III), a nationwide registry of ischaemic stroke or transient ischaemic attack (TIA) in China based on aetiology, imaging and biology markers, will be considered to clarify the pathogenesis and prognostic factors of ischaemic stroke. Methods: Between August 2015 and March 2018, the CNSR-III recruited consecutive patients with ischaemic stroke or TIA from 201 hospitals that cover 22 provinces and four municipalities in China. Clinical data were collected prospectively using an electronic data capture system by face-to-face interviews. Patients were followed for clinical outcomes at 3 months, 6 months and 1-5 year annually. Brain imaging, including brain MRI and CT, were completed at baseline. Blood samples were collected and biomarkers were tested at baseline. Results: A total of 15 166 stroke patients were enrolled, among which 31.7% patients were women with the average age of 62.2±11.3 years. Ischaemic stroke was predominant (93.3%, n=14 146) and 1020 (6.7%) TIAs were enrolled. Conclusions: CNSR-III is a large scale nationwide registry in China. Data from this prospective registry may provide opportunity to evaluate imaging and biomarker prognostic determinants of stroke. © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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大类 | 1 区 医学
小类 | 2 区 临床神经病学
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Q1 CLINICAL NEUROLOGY

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第一作者机构: [1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China [2]China National Clinical Research Center for Neurological Diseases, Beijing, China [3]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China [4]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
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通讯机构: [1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China [2]China National Clinical Research Center for Neurological Diseases, Beijing, China [3]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China [4]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
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