机构：[1]Department of Neurology, Beijing Tiantan hospital, Capital Medical University, Beijing, China重点科室诊疗科室神经病学中心首都医科大学附属天坛医院[2]China National Clinical Research Centre for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China重点科室诊疗科室神经病学中心首都医科大学附属天坛医院[3]Beijing Key laboratory of Translational Medicine for Cerebrovascular Disease, Gurukula Kangri Vishwavidyalaya, Beijing, China[4]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
Objectives: Although statin therapy is associated with lower recurrence in patients with acute ischaemic stroke, data-evaluating associations between inpatient statin use and stroke recurrence in diabetic patients after acute stroke onset are limited. Methods: This study was based on population data from the Chinese National Stroke Registry. Patients with acute ischaemic stroke and no history of statin therapy were selected. Individuals treated regularly with any type or dosage of statins during acute hospitalization were defined as having inpatient statin therapy. The subjects were divided into two groups according to statin use status during acute hospitalization. Multivariate logistic regression analysis was used to analyse the associations between statin use and stroke recurrence in patients with or without diabetes. Results: A total of 11,429 patients, 2341 (20.48%) with diabetes, were selected for analysis. Statin therapy during hospitalization was documented in 4982 (43.59%). Logistic analysis showed no significant associations between inpatient statin use and stroke recurrence in diabetic subjects at 3 months (OR = 0.90, 95% CI = 0.69-1.16, P = 0.40) or 1 year (OR = 0.92, 95% CI = 0.74-1.16, P = 0.48), but statin use was significantly associated with lower recurrence in non-diabetic patients at both 3 months (OR = 0.80, 95% CI = 0.69-0.92, P = 0.002) and 1 year (OR = 0.82, 95% CI = 0.72-0.93, P = 0.002) after discharge. Conclusion: Inpatient statin use was associated with lower stroke recurrence in non-diabetic patients after acute ischaemic stroke, but no definite association between inpatient statin use and stroke recurrence in patients with diabetes mellitus was found.
基金：
This study was supported by the National Key Research
and Development Program of the Ministry of Science and
Technology of The People’s Republic of China (grant numbers
2016YFC0901001, 2016YFC0901002, and
2017YFC1310901), Beijing Municipal Science &
Technology Commission (D151100002015003), Beijing
Municipal Administration of Hospitals’ Mission Plan
(SML20150502), Beijing Municipal Administration of
Hospitals (PX2016052) and National Natural Science
Foundation of China (81600999).
第一作者机构：[1]Department of Neurology, Beijing Tiantan hospital, Capital Medical University, Beijing, China[2]China National Clinical Research Centre for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China[3]Beijing Key laboratory of Translational Medicine for Cerebrovascular Disease, Gurukula Kangri Vishwavidyalaya, Beijing, China[4]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, Beijing Tiantan hospital, Capital Medical University, Beijing, China[2]China National Clinical Research Centre for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China[3]Beijing Key laboratory of Translational Medicine for Cerebrovascular Disease, Gurukula Kangri Vishwavidyalaya, Beijing, China[4]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China[*1]China National Clinical Research Centre for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, No. 119 South 4th Ring West Road, Fengtai District, Beijing 100070, China
推荐引用方式(GB/T 7714)：
Zhang Xing,Li Shu-Ya,Jing Jing,et al.Inpatient statin use and stroke recurrence in patients with or without diabetes mellitus.[J].NEUROLOGICAL RESEARCH.2019,41(10):1-7.doi:10.1080/01616412.2019.1642436.
APA：
Zhang Xing,Li Shu-Ya,Jing Jing,Pan Yue-Song,Yan Hong-Yi...&Wang Yong-Jun.(2019).Inpatient statin use and stroke recurrence in patients with or without diabetes mellitus..NEUROLOGICAL RESEARCH,41,(10)
MLA：
Zhang Xing,et al."Inpatient statin use and stroke recurrence in patients with or without diabetes mellitus.".NEUROLOGICAL RESEARCH 41..10(2019):1-7
