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Platelet-rich fibrin/aspirin complex promotes alveolar bone regeneration in periodontal defect in rats

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资源类型：

收录情况： ◇ SCIE

作者：
J. Du[1] * ; S. Mei[2] ; L. Guo[3] ; Y. Su[4] ; H. Wang[4] ; Y. Liu[1] ; Z. Zhao[2] ; S. Wang[5] ; Y. Liu[1,*1] ;
机构： [1]Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, Beijing, China [2]Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, China [3]Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing, China [4]Department of Stomatology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China [5]Salivary Gland Disease Center and Molecular Laboratory for Gene Therapy and Tooth Regeneration, School of Stomatology, Capital Medical University, Beijing, China
出处：
DOI： 10.1111/jre.12485
ISSN：

关键词： aspirin bone regeneration periodontal disease platelet-rich fibrin tissue engineering

摘要：
Background and ObjectivesThe efficacy and outcomes of aspirin in local defects and the use of platelet-rich fibrin (PRF) in periodontal defects were investigated. Whether the PRF/aspirin complex is a suitable scaffold and delivery system to carry sustained-release aspirin/salicylic acid to promote periodontal bone regeneration was determined. Material and MethodsPRF and PRF/aspirin complex were prepared. The concentrations of aspirin/salicylic acid released from the PRF/aspirin complex were calculated at 37 degrees C. Periodontal ligament mesenchymal cells were cultured on six-well plates with PRF or PRF/aspirin complex gel to analyze proliferation and migration. The alveolar bone between the inferior buccal mesial root and anterior buccal distal root of the first maxillary molar was removed in 15 rats randomly divided into three groups: no treatment, PRF or PRF/aspirin complex. Twelve weeks post-transplantation, 2D/3D micro-computed tomography and histomorphometric technique were used for quantitative analyses. ResultsThe PRF/aspirin complex provided a sustained-release aspirin/salicylic acid. Peak concentrations occurred 4hours after transplantation and were sustained to 48hours at 37 degrees C; the total concentration of released aspirin/salicylic acid was 83.5mg/mL, respectively. The sustained-release promoted the proliferation and migration of periodontal ligament mesenchymal cells. Micro-computed tomography and histological data showed that both the PRF and PRF/aspirin complex enhanced periodontal bone formation (P<.05). Moreover, the new bone formation was two times greater in the PRF/aspirin complex group than the PRF group. ConclusionAspirin/salicylic acid could be sustained-released from PRF/aspirin complex, which could inhibit inflammation and improve the function of mesenchymal cells. The data might provide a new safe and easy clinical therapeutic strategy to promote periodontal bone reparation.

基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81470751, 81222011]; Discipline Construction Foundation of Beijing Stomatological Hospital [15-09-02]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类 | 3 区 医学
小类 | 2 区 牙科与口腔外科
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 牙科与口腔外科
JCR分区：
出版当年[2016]版：
Q1 DENTISTRY, ORAL SURGERY & MEDICINE
最新[2023]版：
Q1 DENTISTRY, ORAL SURGERY & MEDICINE

影响因子： 最新[2023版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

第一作者：
第一作者机构： [1]Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, Beijing, China
通讯作者：
通讯机构： [1]Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, Beijing, China [*1]Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, Beijing, China.
推荐引用方式(GB/T 7714)：
J. Du,S. Mei,L. Guo,et al.Platelet-rich fibrin/aspirin complex promotes alveolar bone regeneration in periodontal defect in rats[J].JOURNAL OF PERIODONTAL RESEARCH.2018,53(1):47-56.doi:10.1111/jre.12485.
APA：
J. Du,S. Mei,L. Guo,Y. Su,H. Wang...&Y. Liu.(2018).Platelet-rich fibrin/aspirin complex promotes alveolar bone regeneration in periodontal defect in rats.JOURNAL OF PERIODONTAL RESEARCH,53,(1)
MLA：
J. Du,et al."Platelet-rich fibrin/aspirin complex promotes alveolar bone regeneration in periodontal defect in rats".JOURNAL OF PERIODONTAL RESEARCH 53..1(2018):47-56

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