Glioma is the most common intracranial malignant tumor. Low-grade gliomas (LGG) occupy almost 80% in all of the gliomas. The prognosis of LGG in children is much better than in adult, however, the molecular mechanism is still unclear. In our investigation, it was first found that the level of soluble IL1RAP (sIL1RAP) was significantly higher in the LGG from children than that from adult. We also revealed that sIL1RAP could induce the apoptosis of U251. In cells with overexpression of sIL-1RAP, the cell proliferation promoted by IL-1 was significantly inhibited. These decreased tumor growth ability and better prognosis of low-grade gliomas in children patients than that in adult patients. The expression level of sIL1RAP may become one of the potential indexes for determining the prognosis of low-grade gliomas.
基金：
National Natural Science Funding, Beijing [31271119]; Beijing Municipal Planning Commission Funding [2013-3-045]
第一作者机构：[1]Capital Med Univ, Beijing Tiantan Hosp, Dept Pediat Neurosurg, Beijing 100050, Peoples R China;
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Tiantan Hosp, Dept Pediat Neurosurg, Beijing 100050, Peoples R China;[2]Capital Med Univ, Beijing Neurosurg Inst, Beijing 100050, Peoples R China
推荐引用方式(GB/T 7714)：
Jintao He,Xiang Li,Wanchun Zhu,et al.Research of differential expression of sIL1RAP in low-grade gliomas between children and adults[J].BRAIN TUMOR PATHOLOGY.2018,35(1):19-28.doi:10.1007/s10014-017-0304-x.
APA：
Jintao He,Xiang Li,Wanchun Zhu,Yaxiong Yu&Jian Gong.(2018).Research of differential expression of sIL1RAP in low-grade gliomas between children and adults.BRAIN TUMOR PATHOLOGY,35,(1)
MLA：
Jintao He,et al."Research of differential expression of sIL1RAP in low-grade gliomas between children and adults".BRAIN TUMOR PATHOLOGY 35..1(2018):19-28
