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An Excitatory Neural Assembly Encodes Short-Term Memory in the Prefrontal Cortex

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收录情况： ◇ SCIE

作者：
Yonglu Tian,[1,2] * ; Chaojuan Yang,[1] * ; Yaxuan Cui,[1] * ; Feng Su,[1,3] * ; Yongjie Wang,[4,5] * ; Yangzhen Wang,[1,6] * ; Peijiang Yuan,[3] ; Shujiang Shang,[1] ; Hao Li,[7,8] ; Jizong Zhao,[7,8] ; Desheng Zhu,[1] ; Shiming Tang,[1] ; Peng Cao,[9] ; Yunbo Liu,[10] ; Xunli Wang,[11] ; Liecheng Wang,[12] ; Wenbo Zeng,[13] ; Haifei Jiang,[13] ; Fei Zhao,[13] ; Minhua Luo,[13] ; Wei Xiong,[6] ; Zilong Qiu,[14] ; Xiang-Yao Li,[5] ; Chen Zhang[1] ;
机构： [1]State Key Laboratory of Membrane Biology, PKU-IDG/McGovern Institute for Brain Research, School of Life Sciences and Key Laboratory for Neuroscience, Ministry of Education/National Health and Family Planning Commission, Peking University, Beijing 100191, China [2]Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China [3]School of Mechanical Engineering and Automation, Beihang University, Beijing 100191, China [4]Center for Mitochondrial Biology and Medicine, and Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi Province 710049, China [5]Department of Physiology, Institute of Neuroscience and Collaborative Innovation Center for Brain Science, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province 310058, China [6]School of Medicine, School of Life Sciences, Tsinghua University, Beijing 100084, China [7]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China [8]China National Clinical Research Center for Neurological Diseases, Beijing 100050, China [9]State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences (CAS), Beijing 100101, China [10]Institute of Laboratory Animal Science, Peking Union Medical College/Chinese Academy of Medical Science, Beijing 100021, China [11]Laboratory Animal Center, Fujian University of Tradition Chinese Medicine, Fuzhou, Fujian Province 350122, China [12]Department of Physiology, Anhui Medical University, Hefei, Anhui Province 230032, China [13]State Key Laboratory of Virology, CAS Center for Excellence in Brain Science and Intelligence Technology, Wuhan Institute of Virology, CAS, Wuhan, Hubei Province 430071, China [14]CAS Key Laboratory of Primate Neurobiology, Institute of Neuroscience, CAS, Shanghai 200031, China
出处：
DOI： 10.1016/j.celrep.2018.01.050
ISSN：

关键词： Alzheimer's disease microcircuitry prefrontal cortex short-term memory

摘要：
Short-term memory (STM) is crucial for animals to hold information for a small period of time. Persistent or recurrent neural activity, together with neural oscillations, is known to encode the STM at the cellular level. However, the coding mechanisms at the microcircuitry level remain a mystery. Here, we performed two-photon imaging on behaving mice to monitor the activity of neuronal microcircuitry. We discovered a neuronal subpopulation in the medial prefrontal cortex (mPFC) that exhibited emergent properties in a context-dependent manner underlying a STM-like behavior paradigm. These neuronal subpopulations exclusively comprise excitatory neurons and mainly represent a group of neurons with stronger functional connections. Microcircuitry plasticity was maintained for minutes and was absent in an animal model of Alzheimer's disease (AD). Thus, these results point to a functional coding mechanism that relies on the emergent behavior of a functionally defined neuronal assembly to encode STM.

基金：
National Basic Research Program of ChinaNational Basic Research Program of China [2017YFA0105201, 2014CB942804]; National Science Foundation of ChinaNational Natural Science Foundation of China [31670842, 61375085]; Beijing Institute of Collaborative Innovation [15I-15-BJ]; Beijing Municipal Science & Technology CommissionBeijing Municipal Science & Technology Commission [Z161100002616021, Z161100000216154]; Seeding Grant for Medicine and Life Sciences of Peking University [2014-MB-11]; SLS-Qidong Innovation Fund
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类 | 1 区 生物
小类 | 2 区 细胞生物学
最新[2023]版：
大类 | 1 区 生物学
小类 | 2 区 细胞生物学
JCR分区：
出版当年[2016]版：
Q1 CELL BIOLOGY
最新[2023]版：
Q1 CELL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

第一作者：
第一作者机构： [1]State Key Laboratory of Membrane Biology, PKU-IDG/McGovern Institute for Brain Research, School of Life Sciences and Key Laboratory for Neuroscience, Ministry of Education/National Health and Family Planning Commission, Peking University, Beijing 100191, China [2]Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China
共同第一作者：
通讯作者：
通讯机构： [1]State Key Laboratory of Membrane Biology, PKU-IDG/McGovern Institute for Brain Research, School of Life Sciences and Key Laboratory for Neuroscience, Ministry of Education/National Health and Family Planning Commission, Peking University, Beijing 100191, China [5]Department of Physiology, Institute of Neuroscience and Collaborative Innovation Center for Brain Science, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province 310058, China [14]CAS Key Laboratory of Primate Neurobiology, Institute of Neuroscience, CAS, Shanghai 200031, China
推荐引用方式(GB/T 7714)：
Yonglu Tian ,Chaojuan Yang ,Yaxuan Cui ,et al.An Excitatory Neural Assembly Encodes Short-Term Memory in the Prefrontal Cortex[J].CELL REPORTS.2018,22(7):1734-1744.doi:10.1016/j.celrep.2018.01.050.
APA：
Yonglu Tian,,Chaojuan Yang,,Yaxuan Cui,,Feng Su,,Yongjie Wang,...&Chen Zhang.(2018).An Excitatory Neural Assembly Encodes Short-Term Memory in the Prefrontal Cortex.CELL REPORTS,22,(7)
MLA：
Yonglu Tian,,et al."An Excitatory Neural Assembly Encodes Short-Term Memory in the Prefrontal Cortex".CELL REPORTS 22..7(2018):1734-1744

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