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Optogenetic stimulation of CA3 pyramidal neurons restores synaptic deficits to improve spatial short-term memory in APP/PS1 mice.

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收录情况： ◇ SCIE

作者：
Yang Qinghu[1,2] * ; Song Da[1] * ; Xie Zhen[1] ; He Guiqiong[3] ; Zhao Juan[1] ; Wang Zhe[4] ; Dong Zhifang[5] ; Zhang Heao[1] ; Yang Liang[1,2] ; Jiang Ming[2] ; Wu Yili[6] ; Shi Qing[7] ; Li Junjie[5] ; Yang Jun[8] ; Bai Zhantao[2] ; Quan Zhenzhen[1] ; Qing Hong[1] ;
机构： [1]Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing, 10008, China [2]College of Life Sciences & Research Center for Resource Peptide Drugs, Shaanxi Engineering & Technological Research Center for Conversation & Utilization of Regional Biological Resources, Yanan University, Yanan, 716000, China [3]Institute of Neuroscience & Department of Anatomy, Chongqing Medical University, Chongqing, 400016, China [4]Advanced Innovation Center for Human Brain Protection & The National Clinical Research Center for Geriatric Disease, Xuanwu Hospital, Capital Medical University, Beijing, 100069, China [5]Ministry of Education Key Laboratory of Child Development and Disorders & Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children’s Hospital of Chongqing Medical University, Chongqing, 400014, China [6] Shandong Collaborative Innovation Center for Diagnosis & Treatment and Behavioral Interventions of mental disorders & Shandong Key Laboratory of Behavioral Medicine, Institute of Mental Health, Jining Medical University, Jining, 272067, China [7]Intelligent Robotics Institute, School of Mechatronical Engineering & Key Laboratory of Biomimetic Robots and Systems (Beijing Institute of Technology), Ministry of Education, 100081, Beijing, China [8]State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing, 100875, China
出处：
DOI： 10.1016/j.pneurobio.2021.102209
ISSN：

关键词： Alzheimer’s disease CA3 Synaptic plasticity Astrocytes Optogenetics Spatial memory

摘要：
The hippocampal CA3 region, that is involved in the encoding and retrieval of spatial memory, is found to be synaptically impaired in the early-onset of Alzheimer's disease (AD). It is reported optogenetic manipulation of DG or CA1 can rescue the memory impairment of APP/PS1 mice, however, how CA3 region contributes to AD-related deficits in cognitive function is still unknown. Our work shows optogenetic stimulation of CA3 pyramidal neurons (PNs) significantly restores the impaired spatial short-term memory of APP/PS1 mice. This enhances the anatomical synaptic density/strength and synaptic plasticity as well as activates astrocytes. Chemogenetic inhibiting the activity of CA3 astrocytes reverses the effect of optogenetic stimulation of CA3 PNs that leads to reduced anatomical synaptic density/strength, decreased synaptic protein and AMPA receptors GluA3/4, thus disrupting the cognitive restoration of APP/PS1 mice. These results reveal the molecular mechanism of optogenetic activation of CA3 PNs on restoration of the spatial short-term memory of APP/PS1 mice and unveil a potential strategy of manipulating CA3 for AD treatment.Copyright © 2021. Published by Elsevier Ltd.

基金：
This work was supported by the National Key Research and Development Program of China (Grant No. 2018YFC1312302-3), the PhD research startup foundation of Yan’an University (Grant No. YDBK2019- 41), the Yan’an High-level Talent Project (Grant No. 203010108), the National Natural Science Foundation of China (Grant Nos. 92049102, 82071395, 31860270, 82101507 & 82001167), the National Key R&D Program of China (Grant No. 2017YFE0117000), and the Chongqing Science and Technology Commission (Grant No. cstc2020jcyjzdxmX0004).
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外文
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中科院(CAS)分区：
出版当年[2021]版：
大类 | 1 区 医学
小类 | 2 区 神经科学
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 神经科学
JCR分区：
出版当年[2020]版：
Q1 NEUROSCIENCES
最新[2023]版：
Q1 NEUROSCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [1]Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing, 10008, China [2]College of Life Sciences & Research Center for Resource Peptide Drugs, Shaanxi Engineering & Technological Research Center for Conversation & Utilization of Regional Biological Resources, Yanan University, Yanan, 716000, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Yang Qinghu,Song Da,Xie Zhen,et al.Optogenetic stimulation of CA3 pyramidal neurons restores synaptic deficits to improve spatial short-term memory in APP/PS1 mice.[J].PROGRESS IN NEUROBIOLOGY.2022,209:102209.doi:10.1016/j.pneurobio.2021.102209.
APA：
Yang Qinghu,Song Da,Xie Zhen,He Guiqiong,Zhao Juan...&Qing Hong.(2022).Optogenetic stimulation of CA3 pyramidal neurons restores synaptic deficits to improve spatial short-term memory in APP/PS1 mice..PROGRESS IN NEUROBIOLOGY,209,
MLA：
Yang Qinghu,et al."Optogenetic stimulation of CA3 pyramidal neurons restores synaptic deficits to improve spatial short-term memory in APP/PS1 mice.".PROGRESS IN NEUROBIOLOGY 209.(2022):102209

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