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A potential biomarker of preclinical Alzheimer's disease: The olfactory dysfunction and its pathogenesis-based neural circuitry impairments.

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收录情况: ◇ SCIE ◇ SSCI

机构: [1]Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing, 100081, China [2]Advanced Innovation Center for Human Brain Protection, Capital Medical University, The National Clinical Research Center for Geriatric Disease, Xuanwu Hospital, Capital Medical University, Beijing, China
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关键词: Olfactory dysfunction Alzheimer’s disease Neural networks Neuronal oscillation Synaptic plasticity

摘要:
The olfactory dysfunction can signal and act as a potential biomarker of preclinical AD. However, the precise regulatory mechanism of olfactory function on the neural pathogenesis of AD is still unclear. The impairment of neural networks in olfaction system has been shown to be tightly associated with AD. As key brain regions of the olfactory system, the olfactory bulb (OB) and the piriform cortex (PCx) have a profound influence on the olfactory function. Therefore, this review will explore the mechanism of olfactory dysfunction in preclinical AD in the perspective of abnormal neural networks in the OB and PCx and their associated brain regions, especially from two aspects of aberrant oscillations and synaptic plasticity damages, which help better understand the underlying mechanism of olfactory neural network damages related to AD.Copyright © 2021 Elsevier Ltd. All rights reserved.

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出版当年[2021]版
大类 | 1 区 心理学
小类 | 1 区 行为科学 2 区 神经科学
最新[2023]版
大类 | 1 区 医学
小类 | 1 区 行为科学 2 区 神经科学
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出版当年[2020]版:
Q1 BEHAVIORAL SCIENCES Q1 NEUROSCIENCES
最新[2023]版:
Q1 NEUROSCIENCES Q1 BEHAVIORAL SCIENCES

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第一作者机构: [1]Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing, 100081, China
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