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Hypersensitive Pneumonitis: an Initial Presentation of Chronic Granulomatous Disease in a Child

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收录情况： ◇ SCIE

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机构： [1]Beijing Children’s Hospital Affiliated to Capital Medical University, National Center for Children’s Health, No. 56 South Lishi Road, Beijing 10045, China

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关键词： Chronic granulomatous disease hypersensitive pneumonitis inflammation granuloma

摘要：

Hypersensitive pneumonitis (HP) is a rare initial presentation of chronic granulomatous disease (CGD), especially in children. CGD presenting as HP may result from exposure to inhaled environmental antigens and be induced by excessive production of inflammatory cytokines due to loss of reactive oxygen species production. We herein describe a 2-year-old boy with CGD caused by a mutation in CYBB gene, who initially presented with HP. The patient developed dry cough, progressive dyspnea, and fever after playing in dusty air in a factory that produced plastic materials containing isocyanates. The patient's symptoms and radiological abnormalities did not improve after antigen avoidance, but disappeared after corticosteroid therapy. Because HP is uncommon in children, we should consider the possibility of CGD in children who present with HP. A prompt diagnosis of CGD is essential to enable initiation of prophylactic antibacterial and antifungal therapies.

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出版当年[2017]版：

大类 | 3 区医学

小类 | 3 区免疫学

最新[2023]版：

大类 | 2 区医学

小类 | 2 区免疫学

JCR分区：

出版当年[2016]版：

Q2 IMMUNOLOGY

最新[2023]版：

Q1 IMMUNOLOGY

影响因子： 7.2 最新[2023版] 6.9 最新五年平均 3.253 出版当年[2016版] 3.198 出版当年五年平均 3.094 出版前一年[2015版] 4.227 出版后一年[2017版]

第一作者：

第一作者机构： [1]Beijing Children’s Hospital Affiliated to Capital Medical University, National Center for Children’s Health, No. 56 South Lishi Road, Beijing 10045, China

通讯作者：

通讯机构： [1]Beijing Children’s Hospital Affiliated to Capital Medical University, National Center for Children’s Health, No. 56 South Lishi Road, Beijing 10045, China

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