机构：[1]Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China[2]Department of Neurosurgery, Baotou Eighth Hospital, Baotou, China[3]Department of Ultrasound, Yan’an University Affiliated Hospital, Yan’an, China[4]Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China临床科室心脏内科中心首都医科大学附属安贞医院[5]Department of Biomedical Informatics, Center for Noncoding RNA Medicine, MOE Key Laboratory of Cardiovascular Sciences, School of Basic Medical Sciences, Peking University, Beijing, China[6]Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China[7]Pathophysiology, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Science of the Ministry of Education Center for Non-coding RNA Medicine, Peking University Health Science Center, Beijing, China[8]Department of Cardiology, Kailuan Hospital, North China University of Science and Technology, Tangshan, China[9]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China重点科室诊疗科室神经病学中心首都医科大学附属天坛医院[10]China National Clinical Research Center for Neurological Diseases, Beijing, China[11]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China[12]Beijing Municipal Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China[13]Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, China首都医科大学附属安贞医院
Cerebral artery stenosis (CAS) is the most important causes of ischaemic stroke. Lipoprotein-associated phospholipase A2 (Lp-PLA2) plays 2 diverse roles in atherosclerosis (pro-inflammatory and anti-inflammatory), and the association between Lp-PLA2 mass and cardiovascular or cerebrovascular events is inconsistent among previous studies. A cross-sectional study including 2012 North Chinese adults aged 40years was performed in 2010-2011 to investigate whether Lp-PLA2 mass is associated with asymptomatic cerebral artery stenosis (ACAS). Serum Lp-PLA2 mass was determined by enzyme-linked immunosorbent assay (ELISA). All participants underwent transcranial Doppler (TCD) and bilateral carotid duplex ultrasound to evaluate intracranial artery stenosis (ICAS) and extracranial arterial stenosis (ECAS). The median serum Lp-PLA2 mass of the participants was 140.74ng/mL (interquartile range: 131.79-158.07ng/mL). The adjusted odds ratio (OR) when comparing the 4th quartile to the 1st quartile of Lp-PLA2 was 1.98 (95% confidence interval (CI): 1.42-2.78), 1.79 (95% CI: 1.08-2.94) and 1.87 (95% CI: 1.28-2.73) for the occurrence of ACAS, asymptomatic ECAS and asymptomatic ICAS, respectively, after controlling for vascular risk factors. These independently significant associations remained statistically significant in the male or elderly subgroups, but not in females or middle-aged participants. Lp-PLA2 mass is positively correlated with subclinical atherosclerosis determined by ACAS, ICAS and ECAS in North Chinese, particularly in male and older participants, suggesting that serum Lp-PLA2 mass might be potential biomarker for the detection of ACAS in the adults.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81673247, 81670294, 81473057, 81370083, 81561128020]; Australian National Health and Medical Research CouncilNational Health and Medical Research Council of Australia [APP1112767]; Capital Health Research and Development of Special [2011-2004-03]; Beijing Nova ProgramBeijing Municipal Science & Technology Commission [Z141107001814058]
第一作者机构：[1]Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[8]Department of Cardiology, Kailuan Hospital, North China University of Science and Technology, Tangshan, China[9]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China[10]China National Clinical Research Center for Neurological Diseases, Beijing, China[11]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China[12]Beijing Municipal Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China[13]Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Wang Youxin,Zhou Bin,Zhou Pingan,et al.Association of lipoprotein-associated phospholipase A2 mass with asymptomatic cerebral artery stenosis[J].JOURNAL OF CELLULAR AND MOLECULAR MEDICINE.2018,22(4):2329-2336.doi:10.1111/jcmm.13521.
APA：
Wang, Youxin,Zhou, Bin,Zhou, Pingan,Yao, Yan,Cui, Qinghua...&Zhou, Yong.(2018).Association of lipoprotein-associated phospholipase A2 mass with asymptomatic cerebral artery stenosis.JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,22,(4)
MLA：
Wang, Youxin,et al."Association of lipoprotein-associated phospholipase A2 mass with asymptomatic cerebral artery stenosis".JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 22..4(2018):2329-2336
医学