机构：[a]Department of Stomatology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China首都医科大学附属天坛医院[b]Department of Anatomy and Cell Biology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA[c]Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing, People’s Republic of China[d]Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, Beijing, People’s Republic of China
Oral microbiome is essential for maintenance of oral cavity health. Imbalanced oral microbiome causes periodontal and other diseases. It is unknown whether oral microbiome affect oral stem cells function. This study used a common clinical antibiotic treatment approach to alter oral microbiome ecology and examine whether oral mesenchymal stem cells (MSCs) are affected. We found that altered oral microbiome resulted gingival MSCs deficiency, leading to a delayed wound healing in male mice. Mechanistically, oral microbiome release lipopolysaccharide (LPS) that stimulates the expression of microRNA-21 (miR-21) and then impair the normal function of gingival MSCs and wound healing process through miR-21/Sp1/telomerase reverse transcriptase pathway. This is the first study indicate that interplay between oral microbiome and MSCs homeostasis in male mice.
基金：
National Institute of Dental and Craniofacial Research, National Institute of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Dental & Craniofacial Research (NIDCR) [K99DE025915]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81600891, 81600829, 81470751, 81222011]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7172087]
第一作者机构：[a]Department of Stomatology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China
通讯作者：
通讯机构：[d]Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, Beijing, People’s Republic of China[*1]Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, Tian Tan Xi Li No. 4, Beijing 100050, People’s Republic of China.
推荐引用方式(GB/T 7714)：
YINGYING SU ,CHIDER CHEN ,LIJIA GUO,et al.Ecological Balance of Oral Microbiota Is Required to Maintain Oral Mesenchymal Stem Cell Homeostasis[J].STEM CELLS.2018,36(4):551-561.doi:10.1002/stem.2762.
APA：
YINGYING SU,,CHIDER CHEN,,LIJIA GUO,JUAN DU,XIAOYAN LI&YI LIU.(2018).Ecological Balance of Oral Microbiota Is Required to Maintain Oral Mesenchymal Stem Cell Homeostasis.STEM CELLS,36,(4)
MLA：
YINGYING SU,,et al."Ecological Balance of Oral Microbiota Is Required to Maintain Oral Mesenchymal Stem Cell Homeostasis".STEM CELLS 36..4(2018):551-561
