资源类型：
期刊
文章类型：
论著
机构：
[1]Cell Therapy Center, Xuanwu Hospital, Capital Medical University, Beijing, China
首都医科大学宣武医院
[2]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China
神经外科
首都医科大学宣武医院
[3]Institute of Hypoxia Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China
首都医科大学宣武医院
[4]China-America Joint Institute for Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China
首都医科大学宣武医院
[5]Department of Neurology, Henry Ford Hospital, Detroit, MI, USA
关键词：
Immunomodulatory
Mesenchymal stem/stromal cells
Neurotrophic
Stroke
Transplantation
摘要：
Mesenchymal stem/stromal cells (MSCs) from different sources have been tested in experimental ischemic stroke and been proved effective in many studies. More understanding of the underlying mechanisms for MSC therapy is essential for improving the therapeutic efficacy and ameliorating or avoiding side effects. In this chapter, we reviewed progress in the field that includes the following aspects: (1) the neurotrophic and immunomodulatory functions of MSCs, the two main mechanisms through which MSCs exert effects in stroke treatment; (2) the aging and senescence of MSCs and their influence on outcome; (3) how autologous MSCs derived from diseased patients may affect the therapeutic effects; (4) different sources of MSCs and comparison of their effects in therapy; and (5) time of transplantation and the delivery methods. © Springer Nature Singapore Pte Ltd. 2017.
第一作者：
Yunqian Guan
第一作者机构：
[1]Cell Therapy Center, Xuanwu Hospital, Capital Medical University, Beijing, China
通讯作者：
Zhiguo Chen
通讯机构：
[1]Cell Therapy Center, Xuanwu Hospital, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Yunqian Guan,Xunming Ji,Jieli Chen,et al.Mesenchymal stem cells for stroke therapy[J].Bone Marrow Stem Cell Therapy for Stroke.2016,doi:10.1007/978-981-10-2929-5_5.
APA：
Yunqian Guan,Xunming Ji,Jieli Chen,Y. Alex Zhang&Zhiguo Chen.(2016).Mesenchymal stem cells for stroke therapy.Bone Marrow Stem Cell Therapy for Stroke,,
MLA：
Yunqian Guan,et al."Mesenchymal stem cells for stroke therapy".Bone Marrow Stem Cell Therapy for Stroke .(2016)
