机构：[1]Department of Neurology, UCLA, Los Angeles, CA, USA[2]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China重点科室诊疗科室神经外科神经外科首都医科大学附属天坛医院[3]Stevens Neuroimaging and Informatics Institute, Department of Neurology, University of Southern California, CA, USA[4]Neurovascular Imaging Research Core and Department of Neurology, UCLA, Los Angeles, CA, USA[5]Neuro-Intensive Care Unit, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China重点科室诊疗科室神经病学中心神经病学中心首都医科大学附属天坛医院[6]Department of Biomathematics, UCLA, Los Angeles, CA, USA[7]Department of Radiology, UCLA, Los Angeles, CA, USA[8]Division of Interventional Neuroradiology and Stroke Center, UCLA, Los Angeles, CA, USA
The purpose of this study was to develop and evaluate a scoring system for assessing reperfusion status based on arterial spin labeled (ASL) perfusion MRI in acute ischemic stroke (AIS) patients receiving thrombolysis and/or endovascular treatment. Pseudo-continuous ASL with background suppressed 3D GRASE was acquired along with DWI in 90 patients within 24 h post-treatment. An automatic reperfusion scoring system (auto-RPS) was devised based on the Alberta Stroke Program Early CT Score (ASPECTS) template, and compared with manual RPS and DWI-ASPECTS. TICI (thrombolysis in cerebral infarction) scores were graded in 48 patients who received endovascular treatment. Favorable outcomes were defined by a modified Rankin Scale score of 0-2 at three months. Auto-RPS was positively correlated with DWI-ASPECTS (r = 0.6, P < 0.001) and was on average 1 point lower than DWI-ASPECTS (P < 0.001). The area under the receiver operating characteristic curve for discriminating poor functional outcome (n = 90) was 0.75 (95% CI, 0.64-0.86) for manual RPS, 0.85 (95% CI, 0.76-0.94) for auto-RPS, and 0.81 (95% CI, 0.71-0.90) for DWI-ASPECTS. Multiple logistic regression analysis in the TICI-graded patients (n = 48) showed that auto-RPS is highly associated with functional outcome (OR = 25.2, 95% CI 4.02-496, P < 0.01). Post treatment auto-RPS within 24 h provides a useful tool to predict functional outcome in AIS patients.
基金：
US National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [UH2NS100614, R01-NS081077, R01-EB014922, R01-NS077706, K23-NS054084, P50-NS044378, UL1TR000124, K24-NS072272]; American Heart AssociationAmerican Heart Association [16POST26430064]
第一作者机构：[1]Department of Neurology, UCLA, Los Angeles, CA, USA[2]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, UCLA, Los Angeles, CA, USA[3]Stevens Neuroimaging and Informatics Institute, Department of Neurology, University of Southern California, CA, USA[*1]Stevens Neuroimaging and Informatics Institute, Department of Neurology, 2025 Zonal Ave, Los Angeles, CA 90033, USA.
推荐引用方式(GB/T 7714)：
Songlin Yu,Samantha J Ma,David S Liebeskind,et al.ASPECTS-based reperfusion status on arterial spin labeling is associated with clinical outcome in acute ischemic stroke patients[J].JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM.2018,38(3):382-392.doi:10.1177/0271678X17697339.
APA：
Songlin Yu,Samantha J Ma,David S Liebeskind,Dandan Yu,Ning Li...&Danny JJ Wang.(2018).ASPECTS-based reperfusion status on arterial spin labeling is associated with clinical outcome in acute ischemic stroke patients.JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM,38,(3)
MLA：
Songlin Yu,et al."ASPECTS-based reperfusion status on arterial spin labeling is associated with clinical outcome in acute ischemic stroke patients".JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 38..3(2018):382-392
医学