机构:[1]Beijing Neurosurgical Insititute, Capital Medical University, Tiantan xili 6#, Beijing 100050, China.[2]Key laboratory of central nervous system injury research, Tiantan xili 6#, Beijing 100050, China.[3]Center of Brain Tumor, Beijing Institute for Brain Disorders, Tiantan xili 6#, Beijing 100050, China.[4]China National Clinical Research Center for Neurological Diseases, Tiantan xili 6#, Beijing 100050, China.[5]Department of Neurosurgery, Xinjiang Uygur Autonomous Region People’s Hospital, Xinjiang 830000, China.
Background: Circulating tumor cells (CTCs) are tumor cells that have shed from a primary tumor and circulate in the peripheral blood. Recent experimental and clinical studies show that CTCs can be detected in early-stage disease. Case presentation: We report three cases of pituitary adenoma (PA) in which tumor cells with particles were detected in the interstitial vascular compartment by transmission electron microscopy. Tumors were completely resected. Immunohistochemical analysis showed a beta-catenin score of 10.5 +/- 1.5 in the three cases with CTCs compared with 2.4 +/- 0.5 in 24 control adenomas. The Ki-67 labeling index was 2.1 +/- 0.7 in CTCs vs. 0.2 +/- 0.3 in control cases (p = 0.043), and the p53 score was 4.33 +/- 1.3 vs. 0.31 +/- 0.17 (p = 0.000). The E-cadherin score did not differ significantly between the two groups. Conclusions: CTCs can be detected in benign tumors such as PAs and not only in late-stage malignant tumors with apparent distant metastases. The present findings suggest that pituitary carcinomas develop from adenomas.
基金:
Beijing Natural Science Foundation of ChinaBeijing Natural Science Foundation [7162035]; Beijing high-level talent plan [2015-3-040]
第一作者机构:[1]Beijing Neurosurgical Insititute, Capital Medical University, Tiantan xili 6#, Beijing 100050, China.[2]Key laboratory of central nervous system injury research, Tiantan xili 6#, Beijing 100050, China.[3]Center of Brain Tumor, Beijing Institute for Brain Disorders, Tiantan xili 6#, Beijing 100050, China.[4]China National Clinical Research Center for Neurological Diseases, Tiantan xili 6#, Beijing 100050, China.
通讯作者:
通讯机构:[1]Beijing Neurosurgical Insititute, Capital Medical University, Tiantan xili 6#, Beijing 100050, China.[2]Key laboratory of central nervous system injury research, Tiantan xili 6#, Beijing 100050, China.[3]Center of Brain Tumor, Beijing Institute for Brain Disorders, Tiantan xili 6#, Beijing 100050, China.[4]China National Clinical Research Center for Neurological Diseases, Tiantan xili 6#, Beijing 100050, China.
推荐引用方式(GB/T 7714):
Gao Hua,He Yanjiao,Liu Qian,et al.Detection of circulating tumor cells in patients with pituitary tumors[J].BMC CANCER.2018,18(1):-.doi:10.1186/s12885-018-4162-7.
APA:
Gao Hua,He Yanjiao,Liu Qian,Wang Jichao&Zhang Yazhuo.(2018).Detection of circulating tumor cells in patients with pituitary tumors.BMC CANCER,18,(1)
MLA:
Gao Hua,et al."Detection of circulating tumor cells in patients with pituitary tumors".BMC CANCER 18..1(2018):-