当前位置: 首页 > 详情页

Detection of circulating tumor cells in patients with pituitary tumors

文献详情

资源类型:

收录情况: ◇ SCIE

机构: [1]Beijing Neurosurgical Insititute, Capital Medical University, Tiantan xili 6#, Beijing 100050, China. [2]Key laboratory of central nervous system injury research, Tiantan xili 6#, Beijing 100050, China. [3]Center of Brain Tumor, Beijing Institute for Brain Disorders, Tiantan xili 6#, Beijing 100050, China. [4]China National Clinical Research Center for Neurological Diseases, Tiantan xili 6#, Beijing 100050, China. [5]Department of Neurosurgery, Xinjiang Uygur Autonomous Region People’s Hospital, Xinjiang 830000, China.
出处:
ISSN:

关键词: Pituitary adenomas Pituitary carcinomas Circulating tumor cells beta catenin Ki 67 p53

摘要:
Background: Circulating tumor cells (CTCs) are tumor cells that have shed from a primary tumor and circulate in the peripheral blood. Recent experimental and clinical studies show that CTCs can be detected in early-stage disease. Case presentation: We report three cases of pituitary adenoma (PA) in which tumor cells with particles were detected in the interstitial vascular compartment by transmission electron microscopy. Tumors were completely resected. Immunohistochemical analysis showed a beta-catenin score of 10.5 +/- 1.5 in the three cases with CTCs compared with 2.4 +/- 0.5 in 24 control adenomas. The Ki-67 labeling index was 2.1 +/- 0.7 in CTCs vs. 0.2 +/- 0.3 in control cases (p = 0.043), and the p53 score was 4.33 +/- 1.3 vs. 0.31 +/- 0.17 (p = 0.000). The E-cadherin score did not differ significantly between the two groups. Conclusions: CTCs can be detected in benign tumors such as PAs and not only in late-stage malignant tumors with apparent distant metastases. The present findings suggest that pituitary carcinomas develop from adenomas.

基金:
语种:
被引次数:
WOS:
PubmedID:
中科院(CAS)分区:
出版当年[2017]版:
大类 | 3 区 医学
小类 | 3 区 肿瘤学
最新[2023]版:
大类 | 2 区 医学
小类 | 3 区 肿瘤学
JCR分区:
出版当年[2016]版:
Q2 ONCOLOGY
最新[2023]版:
Q2 ONCOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

第一作者:
第一作者机构: [1]Beijing Neurosurgical Insititute, Capital Medical University, Tiantan xili 6#, Beijing 100050, China. [2]Key laboratory of central nervous system injury research, Tiantan xili 6#, Beijing 100050, China. [3]Center of Brain Tumor, Beijing Institute for Brain Disorders, Tiantan xili 6#, Beijing 100050, China. [4]China National Clinical Research Center for Neurological Diseases, Tiantan xili 6#, Beijing 100050, China.
通讯作者:
通讯机构: [1]Beijing Neurosurgical Insititute, Capital Medical University, Tiantan xili 6#, Beijing 100050, China. [2]Key laboratory of central nervous system injury research, Tiantan xili 6#, Beijing 100050, China. [3]Center of Brain Tumor, Beijing Institute for Brain Disorders, Tiantan xili 6#, Beijing 100050, China. [4]China National Clinical Research Center for Neurological Diseases, Tiantan xili 6#, Beijing 100050, China.
推荐引用方式(GB/T 7714):
APA:
MLA:

资源点击量:16409 今日访问量:0 总访问量:869 更新日期:2025-01-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 首都医科大学宣武医院 技术支持:重庆聚合科技有限公司 地址:北京市西城区长椿街45号宣武医院