Background: Transforming growth factor-beta (TGF-beta) signaling plays important roles in tumor development. Nevertheless, the roles of TGF-beta/Smad signaling in nonfunctioning pituitary adenomas (NFPAs) have not been fully studied. Methods: Tumor samples were obtained from patients who had NFPAs and underwent endoscopic transsphenoidal surgery or craniotomy at Beijing Tiantan Hospital from March 2008 to December 2012. Immunohistochemistry was performed to determine the expression of Smad transducer proteins in NFPAs. Ki-67 was evaluated as an indicator of the proliferative activity of NFPAs. Results: A total of 161 patients with NFPAs were identified; 59 (36.6%) had invasive NFPAs and 102 (63.4%) had noninvasive NFPAs. Protein levels of Smad3 and phospho-Smad3 (p-Smad3) were significantly lower in patients with invasive NFPAs than in patients with noninvasive NFPAs (P < 0.05 and P < 0.01, respectively). The Ki-67 index was markedly greater in invasive NFPAs than in noninvasive NFPAs (P < 0.05) and was significant correlated with p-Smad3 levels (P < 0.05, r=-0.702). Conclusion: A low level of Smad3 and p-Smad3 proteins was associated with the invasion of NFPAs.
基金：
National High Technology Research and Development Program of China (863 Program)National High Technology Research and Development Program of China [2014AA020610]; Research Special Fund for Public Welfare Industry of Health [201402008]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [31200796]
第一作者机构：[1]Capital Med Univ, Beijing Neurosurg Inst, 6 Tiantan Xili, Beijing 100050, Peoples R China;[2]Capital Med Univ, Beijing Tiantan Hosp, Beijing Inst Brain Disorders, Brain Tumor Ctr, Beijing, Peoples R China;
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Neurosurg Inst, 6 Tiantan Xili, Beijing 100050, Peoples R China;[2]Capital Med Univ, Beijing Tiantan Hosp, Beijing Inst Brain Disorders, Brain Tumor Ctr, Beijing, Peoples R China;[3]Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China;
推荐引用方式(GB/T 7714)：
Liu Chunhui,Li Zhenye,Wu Dan,et al.Smad3 and phospho-Smad3 are potential markers of invasive nonfunctioning pituitary adenomas[J].ONCOTARGETS AND THERAPY.2016,9:2265-2271.doi:10.2147/OTT.S99699.
APA：
Liu, Chunhui,Li, Zhenye,Wu, Dan,Li, Chuzhong&Zhang, Yazhuo.(2016).Smad3 and phospho-Smad3 are potential markers of invasive nonfunctioning pituitary adenomas.ONCOTARGETS AND THERAPY,9,
MLA：
Liu, Chunhui,et al."Smad3 and phospho-Smad3 are potential markers of invasive nonfunctioning pituitary adenomas".ONCOTARGETS AND THERAPY 9.(2016):2265-2271
